Abinantha Raju, A (2015) Comparison of antibody titers between third and fourth IM [intramuscular] dose of anti rabies vaccination following post exposure prophylaxis with anti-rabies. Masters thesis, Madras Medical College, Chennai.
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Abstract
Rabies is a fatal encephalitis transmitted to humans by the bite of rabid animals. Which is the most common mode of transmission in our country. Right now the important focus is on the post exposure prophylaxis since no effective treatment options are available till date. Over the course of time post exposure prophylaxis has been changing mainly because of the production of more potent vaccines and better understanding in the field of immune response for vaccination against rabies. In our study we try to find out the effectiveness between the third and fourth dose of anti-rabies vaccination used in post exposure prophylaxis when given via intramuscular route. RAPID FLOURESCENT FOCUS INHIBITION TEST was used to measure the level of antibodies after seven days of each corresponding doses of vaccination. If the adequate levels of antibodies were reached after the third dose and also if no significant increase in antibody titer after the fourth dose, the need for the fourth dose in the schedule can be eliminated. In our study we also try to assess the knowledge, attitude and practice regarding dog bite among the patients coming for post exposure prophylaxis. Conclusion: In our study we found that the adequate levels of antibodies are reached even after the third dose itself, but the increase in antibody titer was highly significant when compared to the third dose. Therefore fourth dose has to be given as per the recommended schedule. In our study we found that the knowledge levels regarding dog bites and rabies are adequate but the attitude and practices are not adequate and needs to be improved.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Dog Bite; Rabies; Post Exposure Prophylaxis; Intradermal Route; Intramuscular Route; Antibody Titers; Rapid Fluorescent Focus Inhibition; Knowledge; Attitude; Practices |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Punitha K |
| Date Deposited: | 03 Aug 2017 11:01 |
| Last Modified: | 09 Aug 2017 03:27 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2489 |
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