Comparison of Serum Calcium levels among patients with alcohol related seizures and primary seizures

Priyadarshini, V (2014) Comparison of Serum Calcium levels among patients with alcohol related seizures and primary seizures. Masters thesis, Kilpauk Medical College, Chennai.


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BACKGROUND : Hypocalcemia can be a contributory factor for epilepsy and previous studies showed that ethanol decreases plasma calcium. Alcohol-related seizures are defined as adult onset seizures that occur in the setting of chronic alcohol dependence. Alcohol-related seizures are typically brief, generalized tonic-clonic seizures that occur 6 to 48 h after the last drink. Alcohol overconsumption induces multiple effects on kidney function as well as on water, electrolyte and acid base homeostasis. Among the electrolyte abnormalities observed in alcoholic patients, Hypocalcemia is a common feature. Thus, the basis of this study is to establish the prevalence of Hypocalcemia in the general convulsive population and to ascertain if there was a specific group of risk for Hypocalcemia among alcoholics. AIM OF THE STUDY : 1. To establish the role of hypocalcemia in alcohol related seizures in contrast to non alcoholic primary idiopathic seizures. 2. To study the prevalence of hypomagnesemia in hypocalcemic patients in both alcohol related seizures and primary idiopathic seizures. MATERIALS AND METHODS : This study was formulated as an analytical case control study. Based on previous records and by obtaining past history of any CNS infections, cerebrovascular accidents, head injury, structural brain lesions, metabolic diseases and illicit drug abuse ,patients with all negative history were screened with investigations such as serum electrolytes, random blood sugar ,serum amylase, serum bilirubin and CT- brain . Among these patients, patients who had all values within normal limits were taken into study population. Among the patients in study population, patients with no history of alcohol consumption with all screening blood investigations within normal limits and those with EEG and CT Brain findings suggestive of primary seizures were grouped into control population. Patients satisfying CAGE criteria with screening blood investigations and CT-Brain normal were grouped into case population. Then, serum calcium levels, serum albumin levels and serum magnesium levels were measured in both cases and controls. Corrected calcium will be calculated in case of hypoalbuminemia. Serum calcium levels were compared in both cases and controls. The prevalence of hypomagnesemia in these patients and their association with hypocalcemia were also assessed secondarily. The results were tabulated and their statistical significance were calculated using pearson’s chi square tests. RESULTS : On comparing the case and control group , 65.2 % of the hypocalcemic patients were in the case group. Only 34.8 % of the patients were in the control group. On applying the chi-square tests, the p value is found to be 0.240. Thus, there is no statistically significant difference in the prevalence of hypocalcemia among the case and control group. On comparing the prevalence of hypomagnesemia among hypocalcemic patients in the case group, the p value is found to be 0.03 which is statistically significant, but p value was not significant in the control group. CONCLUSION : A high prevalence of Hypocalcemia among alcohol related seizures were identified in this study ,though a statistical significance against primary seizures could not be proven. The prevalence of Hypomagnesemia was statistically significant in the Hypocalcemic alcoholic patients. Thus, hypomagnesemia as a cause of seizures in these patients needs further studies.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Alcohol related seizures, hypocalcemia, hypomagnesemia.
Subjects: MEDICAL > General Medicine
Depositing User: Punitha K
Date Deposited: 01 Aug 2017 05:35
Last Modified: 04 Feb 2018 02:10

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