Corneal and lenticular pigmentation following long term chlorpromazine therapy and its significance in causing visual defects.

Sathish, V (2007) Corneal and lenticular pigmentation following long term chlorpromazine therapy and its significance in causing visual defects. Masters thesis, Madras Medical College, Chennai.

[img]
Preview
Text
2203001sathishv.pdf

Download (13MB) | Preview

Abstract

INTRODUCTION: For a clear image to be formed on the retina, the transparency of cornea and lens is essential. Cornea contributes to two-thirds of refractive power and lens to one- third of refractive power. In the visible range of spectrum (380 to 760 nm), the cornea transmits almost 100% of light energy. AIM OF THE STUDY: 1) To evaluate the incidence of lenticular and corneal pigmentation with dose and duration of chlorpromazine therapy. 2 To evaluate the significance of lenticular and corneal pigmentation in causing visual defects . MATERIALS AND METHODS: This clinical study was done to evaluate the incidence of corneal and lenticular pigmentation in patients with long term chlorpromazine therapy and its significance in causing visual defects. The study design was a cross-sectional study conducted in Institute of Mental Health , Ayanavaram, Chennai. The patients included in this study were in-patients residing in the Institute of Mental Health . A total of 100 patients, 50 males and 50 female patients were studied. DISCUSSION: The ocular changes associated with chlorpromazine therapy are dose related. The most prevalent ocular side effects associated with chlorpromazine therapy are anterior capsular and subcapsular pigmentation followed by corneal endothelial pigmentary changes. Both conditions do not affect visual acuity significantly. (Ref- Clinical Ocular pharmacology-fourth edition-Jimmy D.Barlett Siret D.jaanus) This study has been directed towards detecting the incidence of corneal and lenticular pigmentation or opacities in 100 mentally ill patients on T. Chlorpromazine for more than 6 months period. SUMMARY: This clinical study was done at Institute of mental health, Ayanavaram. A total of 100 mentally ill patients were evaluated, 50 male and 50 female patients. Relevant data collected from each patients and they were subjected to a detailed ophthalmic evaluation. CONCLUSION: Lenticular and corneal pigmentary changes are the most significant ocular side effects of long term therapy with Chlorpromazine in mentally ill patients. Detailed ophthalmological evaluation by an ophthalmologist should be made mandatory before starting a patient on Chlorpromazine. Patients on long term Chlorpromazine should be subjected for detailed ophthalmic evaluation periodically (Every 2 years in first 10 years and annually thereafter. If the dosage is more than 200mg/day, evaluation should be done in annual basis). The present scenario in rehabilitating the mentally ill patients, other specialist like Ophthalmologist should also play a major role with Psychiatrist to make the patients in leading a dignified independent life.

Item Type: Thesis (Masters)
Uncontrolled Keywords: corneal and lenticular pigmentation; long term chlorpromazine therapy; visual defects
Subjects: MEDICAL > Ophthalmology
Depositing User: Devi S
Date Deposited: 31 Jul 2017 11:58
Last Modified: 31 Jul 2017 11:58
URI: http://repository-tnmgrmu.ac.in/id/eprint/2401

Actions (login required)

View Item View Item