Comparative study of single dose prophylactic antibiotic versus empirical postoperative antibiotcs in prevention of SSI.

Alex Franklin, K (2016) Comparative study of single dose prophylactic antibiotic versus empirical postoperative antibiotcs in prevention of SSI. Masters thesis, Chengalpattu Medical College, Chengalpattu.

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Abstract

This study includes 100 clean and clean contaminated cases randomized to groups of 50 each. The study group will receive a single dose of antibiotic preoperatively while the control group will receive 3 to 5 days of empirical antibiotic therapy. All the clean class 1 cases in the study group were given a single dose of 1gm of inj. Ceftriaxone at the time of induction or 30 minutes before skin incision in case the procedure is prolonged for more than 3 hrs a second dose was given. They received no further antibiotics i.v or oral. All the cases in the control group received 5 days of inj. Cefotaxime 1Gm iv BD for 5 days. The incidence of SSI was noted and analysed. All the class 2 cases in study group received inj. Ceftriaxone 1gm and inj. Metronidazole 500 mg iv 30 minutes before the skin incision. In case the procedure was extended beyond 3 hrs a second dose was given. They received no further antibiotics i.v or oral. All the cases in the control group received inj. Cefotaxime 1gm iv BD along with inj. Metronidazole 500 mg i.v TDS for 5 days. In case of underweight or obese patients the dose was adjusted according to their body weight. All the cases were followed up at 8th POD,15th POD, 30th POD and later at 3 months and 6 months. Any wound related complications noted and data obtained. The incidence of SSI in both the groups was calculated and results analysed. CONCLUSION: Based on my study I would like to conclude that it is recommendable to use single dose antibiotic prophylaxis using appropriate antibiotics for all class I and Class II cases, as per the study results there is no significant difference in incidence of SSI when compared to the traditional regimes with the added advantage of significant reduction in hospital stay, with its resultant savings in resources. In addition as the use of antibiotics is reduced it further results in increased cost effectiveness and reduces the incidence of complications due to antibiotic overuse.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Surgical Site Infection; Single Dose Antibiotic Prophylaxis; Post Operative Antibiotics; Class I surgeries; Class II surgeries 7. Hernioplasty, 8. Open Appendicectomy 9. Post operative wound Infection.
Subjects: MEDICAL > General Surgery
Depositing User: Punitha K
Date Deposited: 31 Jul 2017 08:04
Last Modified: 28 Sep 2017 03:07
URI: http://repository-tnmgrmu.ac.in/id/eprint/2385

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