Sujitkumar, Sajja (2013) Formulation and In-Vitro Evaluation of Orally Administered Gastro-Retentive Floating Tablets of Imatinib. Masters thesis, K K College of Pharmacy, Chennai, Tamil Nadu, India.
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Abstract
Oral drug delivery is the most desirable and preferred method of administering therapeutic agents for systemic effects. In addition oral medication is the first avenue investigated in the discovery and development of new drug entities and pharmaceutical formulations mainly because of patient acceptance, convenience in administration and cost effective manufacturing process. For many drug substances, conventional immediate release formulations provide clinically effective therapy while maintaining the required balance of pharmacokinetic and pharmacodynamic profiles with an acceptable level of safety to the patient. A total of 6 trials were formulated by direct compression method by using different polymers to find out the ideal formulation which can release the drug in a controlled manner over a period of 20 hours. Based on pre compression, post compression parameters and the drug release profile F4 was selected as the ideal formulation. When the drug release was fitted in pharmacokinetic modeling the ideal formulation F4 was releasing in first order process with fickian diffusion. The ideal formulation F4 was subjected to stability studies and found that there is no deviation of drug release to that of initial release. Therefore we conclude that a stable & effective dosage form giving the required drug release in a controlled manner was successfully formulated.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Formulation; In-Vitro Evaluation; Orally Administered Gastro; Retentive Floating ; Tablets of Imatinib |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 22 Jun 2017 07:08 |
| Last Modified: | 22 Jun 2017 07:08 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/234 |
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