Factors influencing theengraftment of haematopoietic stem cell transplantion in patients with hematological malignancy

Sivaramakrishnan, A (2016) Factors influencing theengraftment of haematopoietic stem cell transplantion in patients with hematological malignancy. Masters thesis, The Tamil Nadu Dr.MGR Medical University, Chennai.


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Haematopoietic stem cell transplantation remains the only curative option for many haematological malignancies. Currently, the majority of procedures for procurement of haematopoietic progenitor cells are performed by peripheral blood apheresis collection. The development of apheresis technology, the discovery of haematopoietic growth factors and small molecule CXCR4 antagonist for stem- cell mobilization and in vivo experimental transplantation studies that eventually led to clinical PBSCT. The quality of PBSC graft be assessed by its speed of engraftment. The advantage of early engraftment of haematopoietic stem cell transplantation include, reduced incidence of post transplant neutropenia associated infections, mortality, morbidity and shorten the length of hospital stay that eventually reduce the overall cost. Furthermore this valuable expensive procedure will be available for more number of patients who are waiting for their disease to be cured. This prospective observational study was undertaken to study (favorable and unfavorable) factors influencing the HSC engraftment. Since early engraftment reduces length of hospital stay, morbidity, mortality and cost of this highly expensive treatment, it is imperative to utilize all available options to enhance the speed of engraftment. In a country like India where there are a few established haematopoietic stem cell transplantation centers available, there are many patients desperately waiting for their life to be saved by this specialized procedure. Hence, successful and faster PBSC graft engraftment is absolutely essential.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Peripheral Blood Stem Cell Transplant (PBSCT) ; Peripheral Blood Stem Cell (PBSC) ; Haematopoietic Stem Cell (HSC) ; Human Leukocyte Antigen(HLA).
Subjects: MEDICAL > Immunohaematology Blood Transfusion
Depositing User: Punitha K
Date Deposited: 28 Jul 2017 10:31
Last Modified: 16 Jun 2019 02:41
URI: http://repository-tnmgrmu.ac.in/id/eprint/2338

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