An Open Clinical Study on Kalladaippu

Govindammal, P (2016) An Open Clinical Study on Kalladaippu. Masters thesis, Government Siddha Medical College, Chennai.

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Abstract

INTRODUCTION: The kalladaippu comes under the classification of “நீரினை அருகல் நோய்” which produces low urine output and dries up the urine and form urinary calculi , due to various aetiological factors.5 Nephrolithiasis or urolithiasis is formation of urinary calculi at any level of the urinary tract. Urinary calculi are worldwide in distribution but are particularly common in some geographic locations such as in parts of the United States, South Africa, India and South- East Asia. It is estimated that approximately 2% of the population experiences renal stone disease at some time in their life with male- female ratio of 2:1. The peak incidence is observed in 2nd to 3rd decades of life. Renal calculi are characterized clinically by colicky pain. AIM: To study the efficacy of the siddha medicine veddiyuppu chendooram both clinically and experimentally for kalladaippu. OBJECTIVES: 1. To study the evaluation of siddha trial drug vediyuppu chendooram for kalladaippu 2. To evaluate the safety profile of the trial drug. 3. To collect the literature of the both siddha and modern aspect related to the disease. 4. To study the disease with deep observation on aetiology, classification, pathology, diagnosis, differential diagnosis, prognosis and treatment by siddha aspect. 5. To gather the diagnostic knowledge by mukutram, udal thathukkal, uyir thathukkal, and en vakai thervugal. 6. To make a clinical observation about the disease in relation of age, sex, occupation, socio economic status. 7. To use modern parameters to confirm the disease. 8. To evaluate • Toxicological analysis-acute and subacute study • physico chemical analysis • pharmacological analysis –lithotriptic activity and • biostatisical analysis of the trial drug. 9. The haematological analysis, urine analysis, ultra sonogram radiological studies will be done to all patients. 10. All patients are subjected to thorough investigation before and after treatment. MATERIALS AND METHODS: Study Design: An open pilot study on kalladaippu was carried out in the post graduate department of maruthuvam in Govt.Siddha Medical College attached to Arignar Anna Hospital of Indian Medicine, Chennai – 106 during the period of 2014 – 2016. The study was approved by Instititional Ethics Committee (IEC) and the approval number is GSMC-CH-ME-3/001/2014. Sample size: The study is conducted in 40 selected kalladaippu patients of both genders between age groups of 18 to 60 years. Selection Criteria: The patients having following parameters are selected for the study. • Pain in the flank. • Burning Micturition. • Oliguria. • Dysuria. • Nausea. • Vomiting. • Haematuria. • Fever. • History of Urolithiasis (with USG-Whole Abdomen reports). Exclusion Criteria: • Age group less than 18. • Stag horn calculus. • Pyonephrosis. • Calculi associated with elevated serum creatinine level. • Calculi in pregnancy. RESULTS : 40 cases having kalladaippu were selected and treated in OPD of PG maruthuvam department attached to AAGHIM, Chennai – 106 during the year 2014 – 2016. The result and observation during that clinical study are as follows. • Gender distribution. • Age distribution. • Occupation. • Socio- economic status. • Dietary habits. • Seasonal occurrence. • Distribution of thinai. • Distribution of mukkutram – vatham. • Distribution of mukkutram – pitham. • Distribution of mukkutram – kabham. • Ezhu udal thathukkal. • En vagai thervugal. • Naadi. • Neikuri. • Clinical features. • Clinical prognosis. • Distribution of calculi based on location. • Grading of results. SUMMARY: I like to summarize this study with the following highlights. Males are more prone to get kalladaippu than females according to my studies. In age distribution, 3rd and 4th decades of people are more affected. Office workers and House wives occupy the first two places in occupational classification. Most of the patient had mixed diet. Higher incidence of cases were noted in pinpani kalam. In the disturbance of Ezhu udal thathukkal, 100% were affected by saaram, 32.5% were affected by enbu and 25% were affected in seneer. In Naadi, most of the patients having 52.5% in azhal vali naadi, 30% in vali azhal naadi. In Neikuri examination 55% were having vatha neer. Among the patients, 100% had flank pain, 50% had burning Micturition, and 20% had Dysuria. 50% patient had bilateral renal calculi, 32.5% patient had right renal calculi. All of my patients were administered with my trial medicine Vediyuppu chendooram– 130- 260 mg bd with mullangi kizhangu chaaru after food for a period of 48 days. After treatment with this trial medicine, most of the symptoms like loin pain, burning Micturition and Dysuria are relieved. The trial medicine shows 60% good result and 25% moderate result and 15% poor result. CONCLUSION: Kalladaippu is a common disorder of pitha kutram. The dearranged pitham is settled down by the trial medicine having astringent taste thereby the medicine acts as ethirurai maruthuvam to cure the disease. • Most of the cases noted in pinpani kalam and munpani kalam in my clinical trial. So, people should take all preventive measures during this period and take enough water. • Toxicological study shows no acute and sub acute toxicity. • Pharmacological study reveals that the trial medicines possess lithotriptic activity. • During clinical trial, no adverse reactions or complications were observed. • The palatability of the trial drug is astringent, so it is easier to consume to the patients. The trial medicine Vediyuppu chendooram showed good results with relieving symptoms in almost 85% patients.

Item Type: Thesis (Masters)
Additional Information: (Reg. No. 321311101)
Uncontrolled Keywords: Kalladaippu.
Subjects: AYUSH > Maruthuvam
Depositing User: Ravindran C
Date Deposited: 28 Jul 2017 07:11
Last Modified: 29 Dec 2018 15:37
URI: http://repository-tnmgrmu.ac.in/id/eprint/2332

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