Prathyusha, Prabhakar (2016) Erythrasma: A Clincal study and a comparative study of topical 2% clotrimazole cream Vs 2% fusidic acid cream in its treatment. Masters thesis, Chengalpattu Medical College, Chengalpattu.
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Abstract
To study the clinical profile of erythrasma and to compare the effectiveness of 2% topical clotrimazole cream vs 2% topical fusidic acid cream in its treatment. MATERIAL AND METHODS : A randomnised prospective, open labeled clinical study and a comparative study of 1 year (Jan 2014-Jan 2015) duration was conducted in 50 patients who were attending the dermatology outpatient department of Chengalpattu Medical College satisfying the inclusion and exclusion criteria after obtaining ethical clearance. METHODOLOGY : The study subjects were first clinically evaluated based on age, sex, morphology, association with other corynebacterial infections, other dermatological lesions and then blood sugar, thyroid levels done. Specific investigations like gram stain ,Wood’s lamp ,skin biopsy and culture being done. Then 25 patients randomly allocated into two groups. Group A patients were treated with 2% clotrimazole cream and group B were treated with 2% fusidic acid cream applied twice daily. The patients were followed up for 2 weeks. The schedule of patient visit is as follows Visit 1 for initial or baseline assessment and follow-up at 7th & 14th day. STATISTICAL ANALYSIS : The data collected were analyzed using Student t test (two tailed,independent) to find the significance of study parameters on continuous scale between two groups. Chi-square/ Fisher Exact test was used to find the significance of study parameters on categorical scale between two or more groups. RESULTS : Erythrasma was found to be common in 58% female patients and 50% were in middle age group. Morphologically reddish brown lesions were found in 88% patients with involvement of groin mostly. 10 cases were associated with keratolysis punctata and 8 cases with trichomycosis axillaris. Diabetes mellitus, hypothyroidism and obesity associated. 2% fusidic acid cream was found to be more effective than 2% clotrimazole cream in reduction of colour intensity, demarcation. scaling and Wood’s lamp reflection score. Side effects were not seen in both groups. CONCLUSIONS : Erythrasma was common in middle aged females with reddish brown lesions in groin. It was found to be associated with keratolysis punctata, trichomycosis axillaris, acanthosis nigricans,acrochordons and systemic diseases like diabetes mellitus, hypothyroidism. 2% fusidic acid cream was found to be effective bactericidal than 2% clotrimazole cream in erythrasma.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Erythrasma ; 2% Clotrimazole Cream ; 2% Fusidic Acid Cream ; Efficacy ; Keratolysis Punctata ; Trichomycosis Axillaris ; Diabetes Mellitus ; Obesity ; Wood’s lamp. |
| Subjects: | MEDICAL > Dermatology Venereology and Leprosy |
| Depositing User: | Punitha K |
| Date Deposited: | 28 Jul 2017 06:09 |
| Last Modified: | 01 Mar 2018 02:23 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2323 |
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