A Study on the profile, management and outcome of Sacrococcygeal Teratoma in children.

Sriram, K (2014) A Study on the profile, management and outcome of Sacrococcygeal Teratoma in children. Masters thesis, Madras Medical College, Chennai.


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INTRODUCTION : Sacrococcygeal Teratoma is a neoplasm arising from the caudal end of spine, usually protruding from the inferior end of the spinal column and displacing the anus forwards. Sacro Coccygeal Teratoma is defined as a tumor emerging from the proliferation of pluri potent cells. They contain tissues from one or more germ cell layers. Though rare it is the most common tumor in the new born period with incidence of 1:35000-45000 live births. Male female ratio is 1: 3-4. They are composed of 2 or 3 germ cell layers, having multiple tissue types. They present in varying sizes and shapes. Sacro Coccygeal Teratoma is tumor of new born which carries good prognosis if diagnosed early and adequate surgical treatment is prompt. AIM : The primary aim is to analyze the clinical profile including epidemiology, clinical presentation, diagnosis (ante natal and post natal),operative findings, and outcome. METHODS : 15 Children with Sacro Coccygeal Teratoma were evaluated clinically, radiologically, and with tumour markers. Subsequently they were subjected to management protocol which included surgery, chemo therapy, and radio therapy. They were followed for 2 years. OBSERVATION AND RESULTS : In our study females were more affected, surgery alone was inadequate for successful management of malignant SCT. We had 5 immature teratoma. Altman type 1 type2 were more common, 46% presented at birth, benign SCT had favorable prognosis, 13% had a pre natal diagnosis, 67% were term, renal anomalies were the most common associated anomaly. CONCLUSION : SCT are a relatively uncommon tumour. Those presenting within a few days of birth carry a better prognosis. Mass is the most common presenting symptom. Early diagnosis, prompt surgical intervention gives good result and long term survival. The optimal therapeutic program for children with malignant SCT is still evolving.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Sacro Coccygeal Teratoma ; Altman type ; tumour marker.
Subjects: MEDICAL > Paediatric Surgery
Depositing User: Kambaraman B
Date Deposited: 28 Jul 2017 03:04
Last Modified: 28 Jul 2017 03:15
URI: http://repository-tnmgrmu.ac.in/id/eprint/2297

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