Clinico-Pathological study of congenital cystic adenomatoid malformation.

Venkatasaravanan, S (2010) Clinico-Pathological study of congenital cystic adenomatoid malformation. Masters thesis, Madras Medical College, Chennai.

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Abstract

INTRODUCTION : Congenital cystic adenomatoid malformation (CCAM) is a rare developmental abnormality of the lung.They are similar to benign lung tumors. The underlying feature of a Congenital cystic adenomatoid malformation is an excessive over growth of terminal respiratory bronchioles, forming cysts of various sizes. This abnormal lung tissue is of defective epithelial-mesenchymal architecture(1,57) The congenital lesions are detectable on prenatal ultrasound. They appear as solid or cystic masses.Mode of presentation of CCAM vary widely in antenatal and neonatal period. AIM : To analyze the effectiveness of ante-natal ultrasonogram. To study the age of presentation of congenital cystic adenomatoid malformation. To analyze the various modes of presentation of congenital cystic adenomatoid malformation. To analyze the pathology of these lesions. Follow up of the cases during the study period. METHODS : It is a combined prospective and retrospective study which included patients with congenital cystic adenomatoid malformation, who attended the pediatric surgery OPD at the Institute of Child Health and Hospital for Children, Madras Medical College, Chennai. The study was done during the three years period, from Jan 1, 2007 to Dec 31, 2009. Inclusion Criteria : All patients had proven congenital cystic adenomatoid malformation radiologically. Exclusion Criteria : All cases of bronchopulmonary sequestration - All cases of congenital lobar emphysema - All mediastinal cystic lesions like bronchogenic cyst, neurenteric cyst, cystic teratoma and pericardial cyst. The patients were subjected to detailed clinical examination and relevant investigations were performed, namely, chest x-ray and CT scan chest. CONCLUSION : Most of CCAM patients present early in life (< 1 year). In our setup the ability of antenatal USG to detect lung lesions is only 39%. Antenatally detected patients , report to the hospital earlier than the other patients. Presenting symptoms vary widely from mild respiratory tract infection to empyema. CT scan chest is the investigation of choice. Antenatally detected patients are usually asymptomatic. Patients with pulmonary infection have a longer hospital stay and have higher incidence of postoperative complications. Majority of our patients (94%) belonged to Stocker type I group. Our patients are free of respiratory problems in their followup.

Item Type: Thesis (Masters)
Uncontrolled Keywords: congenital cystic adenomatoid malformation ; Clinico-Pathological study.
Subjects: MEDICAL > Paediatric Surgery
Depositing User: Kambaraman B
Date Deposited: 28 Jul 2017 03:01
Last Modified: 28 Jul 2017 03:01
URI: http://repository-tnmgrmu.ac.in/id/eprint/2292

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