Vehkatesh, Surisetty (2014) Quantitative Estimation, Analytical Method Development and Validation for Drugs acting on Central Nervous System. Masters thesis, Edayathangudy G.S. Pillay College of Pharmacy, Nagapattinam.
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Abstract
A drug1 may be defined as substance meant for diagnosis, cure, mitigation, prevention and treatment of disease in human beings or animals, for altering any structure or function of the body of human beings or animals2. Pharmaceutical chemistry3-6 is a science that makes use of general laws of chemistry to study drugs i.e. their preparation, chemical nature, composition, structure, influence on an organism, the methods of quality control and the conditions of their storage etc. The family of drugs may be broadly classified as Pharmacodynamic agents and Chemotherapeutic agents. The present study Pregabalin is an anticonvulsant drug used for neuropathic pain and as an adjunct therapy for partial seizures with or without secondary generalization in adults. Chemically pregabalin is [S-[+]-3-isobutyl GABA or (S)-3-(amino methyl)-5-methylhexanoic acid. It binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues. The drug is available in capsule dosage form. In previous reports high performance liquid chromatographic methods and only few spectrophotometric methods were developed. Need for the development of simple spectrophotometric methods for its assay is highly demanding. In the view of above fact, some simple analytical methods were planned to develop with sensitivity, accuracy, precision and economical. Since pregabalin is soluble in distilled water and methanol, a number of spectrophotometric methods can be developed for the quantitative estimation of drug in bulk and pharmaceutical formulations.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Analytical Method ; Validation ; Drugs ; Central Nervous System. |
| Subjects: | PHARMACY > Pharmaceutical Analysis |
| Depositing User: | Ravindran C |
| Date Deposited: | 27 Jul 2017 09:36 |
| Last Modified: | 12 Oct 2017 02:41 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2274 |
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