Prabananthan, A (2013) Development and Validation of Analytical Methods for the Simultaneous Estimation of Telmisartan and Chlorthalidone in Bulk and In Pharmaceutical Dosage Form. Masters thesis, Adhiparasakthi College of Pharmacy, Melmaruvathur.
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Abstract
Analytical chemistry is a metrological discipline that develops, optimizes and applied measurement processes intended to derive quality (bio) chemical information of global and artial type from natural and artificial objects or systems in order to solve analytical problems derived from information needs. Thus, Analytical chemistry has two main aims are Qualitative (intrinsic) and Quantitative (Extrinsic). The Qualitative aim is the achievement of metrological quality, i.e. ensuring full consistency between the analytical results delivered and the actual value of the measured parameters; in metrological terms, this translates into producing high traceable results subject to very little uncertainty. The Quantitative aim is solving the analytical problems derived from the (bio) chemical information needs posed by a variety of “clients”. instrumental analytical methods were successfully developed for the simultaneous estimation of Telmisartan and Chlorthalidone in bulk and in pharmaceutical dosage form. The three methods were found to be accurate, precise and rapid for the simultaneous estimation of these drugs. This was confirmed by low percentage RSD values. The spectrophotometric method is found to be economical when compared to the HPLC and HPTLC method. But HPLC and HPTLC is more sensitive than UV spectrophotometric method. The low percentage RSD value in the recovery studies suggests that the excipients do not interfere in the analysis of formulation and hence all the methods are accurate. HPLC and HPTLC are found to be more sensitive than other method. Because the linearity range, LOD, LOQ were less in HPLC and HPTLC method than UV spectroscopic method. Hence it is suggested that these three methods can be applied successfully for the routine quality control analysis for the simultaneous estimation of Telmisartan and Chlorthalidone in bulk and in pharmaceutical dosage form and the obtained results will be presented elsewhere.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Analytical Methods; Simultaneous; Telmisartan; Chlorthalidone; Pharmaceutical Dosage |
| Subjects: | PHARMACY > Pharmaceutical Analysis |
| Depositing User: | Ravindran C |
| Date Deposited: | 27 Jul 2017 07:53 |
| Last Modified: | 06 Oct 2017 03:44 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2262 |
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