Niharika, Nandi (2014) Method Development and Validation of Simultaneous Estimation of Olmesartan Medoximil and Cilnidipine by RP-HPLC In Pharmaceutical Dosage Form. Masters thesis, C L Baid Metha College of Pharmacy, Chennai.
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Abstract
Pharmaceutical analysis plays a vital role in the pharmaceutical product development. Pharmaceutical analysis is a specialized branch of analytical chemistry. Analytical chemistry involves separating, identifying, and determining the relative amounts of components in a sample matrix. In order to develop a Liquid Chromatographic method effectively, most of the effort should be spent in method development and optimization as this will improve the final method performance.The method validations documents for its intended purpose. A fast isocratic HPLC-PDA method was developed for the estimation of Olmesartan Medoximil and Olmesartan in tablet dosage form. The total run time was 8 minutes. Simple buffer was used. The mobile phases were easy to prepare and economical. The baseline with low signal to noise ratio was obtained. Each peak eluted with good resolution and no carryover was observed. Since the solutions were stable only for 24 hrs at room temperature. The purity of each peak was observed in PDA, from which an inference can be drawn that there is no interference of other peaks in the particular peak. The method allows high samples through put due to short run time. Thus, selective, simple and rapid method was developed. The method was validated with different analytical performance characteristics and data was compiled. The results satisfied the acceptance criteria. This demonstrated that the HPLC method developed was specific, linear, accurate, precise and robust. This work provided me a great opportunity to have an exposure with the instruments used in Pharmaceutical Industry.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Validation ; Simultaneous ; Olmesartan Medoximil ; Cilnidipine ; Pharmaceutical Dosage. |
| Subjects: | PHARMACY > Pharmaceutical Analysis |
| Depositing User: | Ravindran C |
| Date Deposited: | 27 Jul 2017 07:50 |
| Last Modified: | 12 Oct 2017 02:25 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2261 |
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