Aswini, S (2023) Serum Homocysteine Level and Its Correlation in Young Coronary Artery Disease Patients Versus in Old Coronary Artery Disease Patients of Coimbatore Population. Masters thesis, Coimbatore Medical College, Coimbatore.
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Abstract
ABSTRACT BACKGROUND Coronary artery disease is a major cause of morbidity and mortality in India and worldwide. Prevention of cad is very essential step in its management. The majority of cad patients have atleast one cardiovascular risk factors (conventional risk factors like smoking, lipids) but 20% of them have no traditional risk factors. one of the novel risk factor is homocysteine. Coronary artery disease are very common in coimbatore population. Young coronary artery disease patients are increasing in number in recent times. A significant rise in numbers have been noted in last 5 years. The reason for this is change in lifestyle with increasing stress, obesity, changing food habits. ❖ Many studies on serum homocysteine levels have already been studied and the relationship between serum homocysteine and coronary artery disease have been established. However many such studies belong to the western population. Indian studies are lacking in number especially in south indian population. As food habits have a great influence on the level of serum homocysteine, change in geography brings a change in lifestyle and dietary habits and ultimately on the risk factors for coronary artery disease. ❖ This study focuses on local environmental factors associated with coronary artery disease. Since homocysteine is a modifyable risk factor it becomes necessary that this study proves its importance. METHODS: Patients getting admitted in Coimbatore medical college hospital as a case of CAD – STEMI, NSTEMI and UNSTABLE ANGINA will be handed over the questionnaire which contains personal details, medical history of patient and overall medical examination of the patient will be done. Patients will be divided into two groups- those less than 40 years of age and those more than 40 years of age. Blood sample will be collected and sent for analysis. Cardiac evaluation of the patient will be done using ECHO. Blood investigations showing patients to be not eligible for study (based on inclusion exclusion criteria) will be excluded. Serum homocysteine levels in remaining patients of the two groups is compared and correlated to the cardiovascular risk. RESULTS: 75 young cad and 75 old cad patients were taken for the study. Age distribution was more in the 30-40 years among the young cad. Sex and population: male cad patients were 63% compared to females which was 37%. Young and old cad patients with respect to gender was comparable. 27 female young cad and 28 old female patients were studied. ❖ Patients with 0 % known comorbidities was taken for study. Ecg findings were such that stemi was 28%, nstemi was 36% and unstable angina was 36%. Cpk mb elevated in majority of cad patients which was 55%. Elevation levels were more in the male population than females. Cpk mb levels were elevated more in the older population compared to younger population. Mean cpk mb level is 70 in young cad and 42 in old patients. ❖ Homocysteine levels were elevated in 41% of the population. Homocysteine levels were elevated more in males than females. Mean homocysteine was 13 in young and 14 in old cad patients. Majority of echo findings were normal. A significant number of young cad patients fall in the age category of 30-40. ❖ Majority of young cad patients had normal lv function when compared to older population Majority of patients presented to emergency department as nstemi In young cad presentation was nstemi followed by unstable angina followed by stemi whereas old cad patients presented with unstable angina followed by nstemi followed by stemi Homocysteine levels were more elevated in males than females However mean serum homocysteine levels were higher in females CONCLUSION: Although serum homocysteine levels are considered to rise with increasing age there has not been a significant difference between rised levels in young versus older population.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.200120103503 |
| Uncontrolled Keywords: | Serum Homocysteine Level, Correlation, Young Coronary Artery Disease Patients, Old Coronary Artery Disease Patients, Coimbatore Population. |
| Subjects: | MEDICAL > General Medicine > MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 24 Mar 2024 13:05 |
| Last Modified: | 24 Mar 2024 13:05 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/21357 |
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