Sivasakthi, R (2019) JNC 7 Guidelines and A Study on Prescription Pattern in Hypertension Patients and Evaluating Drug related outcomes. Doctoral thesis, The Tamil Nadu Dr.M.G.R. Medical University, Chennai.
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Abstract
MODULE 1: ADR MONITORING: The spread of adverse drug reaction in our general public is expressed relentlessly. The reasons are, despicable patient counseling, silly utilization of medicines, absence of patient-endorses correspondence. It is likewise presumed that, the co-appointment amongst HCPs & patients is imperative to enhance the nature of treatment & to keep the future happenings of adverse drug reaction. For that reason, more consideration regarding be given around the pharmacovigilance of the drug. It might be likely to report all such adverse drug reactions which may be valuable for treatment of diseases & better patient care. MODULE2: PRESCRIPTION PATTERN: This imminent, randomized study on evaluation of endorsing pattern for HTN affirmed that immunotherapy was recommended than the combination treatment. Indicate amid the regulations Circle diuretics were the most every now & again recommended drug class took after by CCB, ARBs, beta blockers, ACEIs, Alpha blockers & α + β blockers. While considering combination treatment, two drug combinations was recommended more than three drug & four drug combinations. In two drug combination, CCB + α blockers was for the most part recommended. Diabetes mellitus is the most customarily happening co-morbidities in hypertensive patients. At the point when contrasted & JNC 8 Regulations it was watched that 28% of prescriptions were balanced & 56% of prescriptions were silly. As to impression of physicians towards JNC 8 regulations it was discovered that greater part were not following JNC 8 regulations. The appraisal of impression of physicians towards expressed regulations demonstrates that 65% of the physicians were agreeable in adjusting to JNC 8 regulations while endorsing AHTN drugs. Along these lines, a more successful refresh of the information is important. It additionally proposes a need of compliance by clinicians amid JNC 8 regulations. This affirms the requirement for clinical drug specialist in every office & mindful the physicians to enhance the adherence to new regulations in clinical setting. MODULE 3: COMPARATIVE STUDIES: The study found that combination treatment was more compelling in decreasing HTN. It was significantly utilized as a part of expansive populace of patient to control BP. Two drug combinations are more powerful & create fewer symptoms. 3 drug combinations ought to be limited to lessen the ADR like hack, palpitation & pedal edema. The study infers that the physicians were recommended the ACEIs for HTN amid different co morbidities according to JNC-7 regulations. The study presumes that the A+E+N is the best combination treatment for better control of HTN. The study demonstrates that the combination treatment can be individualized by the nearness of co morbidities amid HTN. The study strongly recommends the patient counseling in conjunction amid drug treatment, diminish drug treatment, Increment intake of potassium & gentle morning walk are more successful in lessening of BP. The finding of the present study shows that Atenolol is the decision of drug for gentle & direct HTN without & symptoms. MODULE: 4 BIOMARKER STUDY: A simple & reasonable technique for potassium estimation in 24 hours urine analysis was empowered us to accomplish the objective circulatory strain in Hypertensive patients. The target dietary Biomarker assessment might be valuable to Interventional contemplates & Healthful change. Henceforth, this Biomarker estimation can be ideally contributed the wellbeing advancement & disease avoidance as prognostic markers on the whole. The study strongly recommends that the soaring intake of potassium may spare over a large portion of a million lives throughout the following decade & has coordinate impact on prevention Cardio vascular diseases independent of its impact on HTN. MODULE 5: INTERVENTION STUDY: The outcome infers that, the Intervention not watch the hugeness of astounding distinction in BMI. The management of BP was accomplished in 95.27% of the study population. The study sealed that, pharmaceutical care Intervention is a basic device to enhance the BP management in HTN patients. Thus, the study recommends the consideration on the disease & enhanced drug specialist, patient & doctor association may encourage drug treatment adjustments for accomplish the objective circulatory strain & drug related results.
| Item Type: | Thesis (Doctoral) |
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| Additional Information: | (Reg.No: 141440021) |
| Uncontrolled Keywords: | Joint National Committee 7 Guidelines, Prescription Pattern, Adverse drug reaction, Hypertension Patients. |
| Subjects: | PHARMACY > Pharmacy Practice |
| Depositing User: | Subramani R |
| Date Deposited: | 17 Jun 2023 04:51 |
| Last Modified: | 17 Jun 2023 04:51 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/21282 |
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