Pooja, R (2021) Method Development and Validation for Simultaneous Estimation of Metformin Hydrochloride and Canagliflozin by RP-HPLC in Bulk and their Pharmaceutical Formulations. Masters thesis, Padmavathi College of Pharmacy, Dharmapuri.
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Abstract
A simple, Accurate, precise method was developed for the simultaneous estimation of the Metformin and Canagliflozin in tablet form the retention times (Rt’s) of Metformin and Canagliflozin were found to be 3.366min and 2.032min. Percentage RSD of the Metformin was found to be 0.8 and for Canagliflozin was 0.54 and the % Recoveries were gained as 100.3% for Metformin and 100.0% for Canagliflozin. LOD, LOQ values are from regression equations of Metformin and Canagliflozin were 0.575, 0.058ppm and 1.741, 0.176ppm resp. Regression equation of Metformin is y = 10531x + 83.14, Canagliflozin is and y = 48794x + 728.2. In this proposed method retention times (Rt’s) were decreased so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.261931003 |
| Uncontrolled Keywords: | Method Development and Validation for Simultaneous Estimation, Metformin Hydrochloride, Canagliflozin, RP-HPLC, Pharmaceutical Formulations. |
| Subjects: | PHARMACY > Pharmaceutical Analysis |
| Depositing User: | Subramani R |
| Date Deposited: | 24 May 2023 02:53 |
| Last Modified: | 24 May 2023 02:53 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/21271 |
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