Anushree, N M (2021) Design, Optimization, Formulation and Evaluation of Sustained Release Tablets of Sumatriptan Succinate. Masters thesis, The Erode College of Pharmacy and Research Institute, Erode.
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Abstract
Sumatriptan Succinate is an Anti-migraine agent which acts as 5-HT receptors agonist. The objective of the present study is to determine the release of Sumatriptan succinate sustained release tablets. The FT-IR study indicated that there is no interaction between the drug and polymer. The tablets were prepared by wet granulation technique using different polymers such as HPMC, Ethyl cellulose and Eudragit RSPO in (50, 75, 100mg) various concentrations. The prepared sustained release tablets were evaluated for thickness, hardness, friability, drug content, in-vitro drug release, kinetic studies and stability studies. From the release studies, the optimized formulation F10 shows better release rate when compared to others. The drug release kinetic data confirmed that all the formulation fit into Higuchi model which shows the R2 value of 0.974 to 0.994. The results of in-vitro release data were fitted to the Korsmeyer Peppa's equation to analyse the release mechanism of the drug from polymeric system. The "n" value was found to be 0.404 to 0.444, indicating the drug release follows Fickian release mechanism.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | Reg.No.261910551 |
| Uncontrolled Keywords: | Design, Optimization, Formulation, Evaluation, Sustained Release Tablets, Sumatriptan Succinate. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Subramani R |
| Date Deposited: | 19 May 2023 01:35 |
| Last Modified: | 19 May 2023 01:35 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/21261 |
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