Rohini Priya, R (2022) An Open Labelled Double Arm Non-Randomised Phase II Clinical Trial, to Compare the Efficacy of Varma Manipulation with Murivukku Choornam (Internal) and Murivu Ennai-II (External) in the treatment of Muzhankaal Muttu Savvu Kaayam. Masters thesis, (Branch VIII - Varma Maruthuvam) Government Siddha Medical College, Palayamkottai.
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Abstract
20 cases of Muzhankaal muttu savvu kaayam was diagnosed clinically based on Text Book of Varma odivu murivu Maruthuvam and Patients were selected which symptoms were co related with knee joint ligament injury and treated with Varma medicines and Varma manipulation for OPD and IPD Post graduate Department of Varma Maruthuvam, Government Siddha Medical College & Hospital, Palayamkottai. An open labelled double arm non randomised phase –II clinical trial, to compare the efficacy of varmam manipulation with Murivukku choornam (Internal) and Murivu ennai (External) in the treatment of Muzhankaal muttu savvu kaayam (knee joint ligament injury) has been chosen for the dissertation work by the author. ❖ Various Siddha and Varmam literatures used to collect informations about Muzhankaal muttu savvu kaayam and trial medicines. • 10 patients were treated with Varmam manipulation with oil application, 10 patients were treated with internal and external medicine. • Varmam manipulation with oil application done for 48 days in Group – I Patients. • Trial medicines are Murivukku choornam – 1gm twice a day after food internal for 48 days, murivu ennai II externally applied for the group II Patients. ❖ Standard operating procedure for both internal and external drugs was standardized. ❖ Standardization of drug Murivukku choornam through both traditional and modern way of techniques had been done. ❖ Acute, Anti – inflammatory & Analgesic activity of the trial drug Murivukku choornam was done. ❖ The study is conducted after the drug being screened by the Screening committee and the trial is also approved by the Institutional Ethical Committee (IEC) and Institutional Animal Ethical Committee (IAEC). A clinical trial was conducted to evaluate the efficacy of trial drugs Murivukku choornam (Internal) and Murivukku ennai II(External). ❖ Pre-clinical toxicity study was done for the trial drug Murivukku choornam using wistar albino rats. Toxicity study in animal was carried Out after obtaining proper permission from Institutional Animal Ethical Committee (IAEC). ❖ All the details about the study and the drugs were informed to the patients in their vernacular language and consent forms. ❖ Before starting the treatment, the blood samples of the selected patients were subjected to investigation and X-ray, MRI were taken. ❖ After the study period the patients were subjected to investigation, clinical assessment and X-ray, MRI were taken. ❖ Clinical assessment of the symptoms were measured by using Koos score. CONCLUSION: The study was conducted with the Patients of Muzhankaal muttu savvu kaayam, all the selected patients was treated with Varmam manipulation, internal medicine Murivukku choornam and Murivu ennai II as external application. ❖ In the preclinical study of pharmacological evaluation of the trial drug shows, • Significant Analgesic effect (Internal medicine – Murivukku choornam). • Significant Anti inflammatory effect (Internal medicine – Murivukku choornam). ❖ In preclinical Acute & Subacute toxicity study of Mur ivukku choornam shows that the drug had no acute, sub-acute toxicity. • Varmam treatment with the oil application showed same improvement as compared to the patients who were treated with internal and external medicine. Hence the study reveals the effectiveness of Trial drug in treating Muzhankaal muttu savvu kaayam. • Clinically, no adverse effects were reported during the trial and the laboratory investigations were also within normal limits. So, the drug is assumed to be safe for human beings. • Hence the study concludes that, the trial drugs are clinically effective in reduction of pain, swelling, restriction of movements. • However further work with large number of patients should be carried out towards finding the ideal dose response.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No: 321918003 |
| Uncontrolled Keywords: | Open Labelled Double Arm Non-Randomised Phase II Clinical Trial, Varma Manipulation, Murivukku Choornam, Murivu Ennai-II, treatment, Muzhankaal Muttu Savvu Kaayam. |
| Subjects: | AYUSH > Maruthuvam |
| Depositing User: | Subramani R |
| Date Deposited: | 10 May 2023 04:41 |
| Last Modified: | 24 Feb 2024 12:39 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/21251 |
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