Selvasankari, E (2022) Standardization on Purification Process of Gaantham (Magnetic Oxide of Iron). Masters thesis, National Institute of Siddha, Chennai.
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Abstract
Siddha system of medicine emphasis, before going to medicine preparation every raw drug must be purified. The concept of Suddhi (purification) in Siddha is not only a process of detoxification, but also a process to enhance the potency and efficacy of the drug. There is no scientific evidence what all the changes occur during the purification process are. ❖ The Purification method of the chosen drug had been selected from the Siddha literature “Therayar yemaka venpa”. The classic method of purification was said by the famous Siddhar Therayar who is known for his excellence in various realm of Siddha medicine. ❖ In this study, 200gm of raw drug Gaantham(Magnetic oxide of iron) was procured from renowned country drug shop in Krishnagiri district. The authentication for raw drug was obtained from siddha central research institute, Chennai- 06. Ponnavari root was collected near the institute at Tamparam sanatorium and the authentication was obtained from National institute of Siddha, Chennai-47. ❖ Then the raw drug was divided into two equal quantities of 100gm. Both part of the raw drug powdered well. One part of the raw drug was taken and kept as such labelled as unpurified Gaantham (S1 ). The other part of the raw drug Gaantham was subjected to purification procedure. ❖ Taken 600 grams root juice of Ponnavarai(Cassia occidentalis) in a pot add 100grams of Gaantham, kept it in the sunlight for a day. Doing this procedure for 10 days, then keep it dry for next 2 days without letting the juice. Repeat the whole procedure for 2 times and wash Gaantham thoroughly to get purified form of Gaantham. Then it was labelled as purified drug Gaantham (S2 ). The qualitative and quantitative analyses were done for both the samples of unpurified and purified raw drug Gaantham ❖ The physico-chemical analysis of the purified Gaantham reveals state of better absorption in the intestine, higher stability, purity, and Water solubility. ❖ The chemical analysis shows the presence of physiologically important metals and minerals such as iron and sodium. ❖ The results of ICPOES analysis indicates the presence of increased concentration of physiologically important minerals. ❖ The results of FTIR analysis show the presence of Fe-O, alkynes and carbonyl, alkyl halide functional groups which are responsible for the therapeutic effect of Gaantham. ❖ The XRD analysis results depicts clearly that the crystalline phase is increased with increase in intensity, which indicates that purified Gaantham is attributed for better bioavailability and dissolution rate. ❖ The VSM analysis results shows that there is a strength of magnetic property of Gaantham decreased after Purification. Lower particle size of magnetite presented in purified magnetite and the magnetic saturation is also lower. This may important for its safety. ❖ The GCMS analysis results shows that there is the presence of 18 compounds in root extract of Cassia occidentalis and responsible for its pharmacological activity. CONCLUSION: The following inferences are drawn based on qualitative and quantitative analysis of before and after purification of Gaantham (Magnetic oxide if iron) with root juice of Ponnavari (Cassia occidentalis). ❖ After purification the total ash value and moisture content are reduced, which denotes the impurities are removed and the shelf life is increased. ❖ Increased Crystalline nature and decreased magnetic property and particle size in purified Gaantham which enriches better bioavailability and dissolution of the drug. Also shows the presence of physiologically important mineral iron. Ponnavarai root has more than fifteen pytochemical constituents, it may enchange the mineral Gaantham during purification process. ❖ The present study of purification process of Gaantham the impurities are removed and the quality of the mineral is improved. Thus the purification turns the Gaantham in to a therapeutic valuable mineral. Therefore the purified drug when used in medicine preparation may increase the efficacy and potency of the medicine. ❖ The changes found in after purification of Gaantham(Magnetic oxide of iron) indicates the necessity of purification. This purification process of Gaantham with root juice of Ponnavarai(Cassia occidentalis) can be set as one of the standard purification process of Gaantham. ❖ So the purification process is essential for any drug of Metal and Mineral origin before using them in the pharmaceutical preparations. If it is properly done as per Siddha literature including preparation of medicine, it will be highly beneficial for mankind. ❖ Therefore it can be concluded that after the purification of Gaantham, through the above purification Method, has more efficacy and fulfill the therapeutic effects.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.321916207 |
| Uncontrolled Keywords: | Standardization, Purification Process, Gaantham, Magnetic Oxide of Iron. |
| Subjects: | AYUSH > Nanju Noolum Maruthuva Neethi Noolum |
| Depositing User: | Subramani R |
| Date Deposited: | 01 May 2023 18:50 |
| Last Modified: | 24 Feb 2024 12:12 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/21239 |
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