Samuvel, D (2022) Standardization of Purification of Indhuppu (Sodium Chloride Impura): A Comparative Analysis. Masters thesis, Government Siddha Medical College, Palayamkottai.
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Abstract
Siddha system of medicine is one of the oldest and foremost of all other medical system of the world. The word siddha comes fro the word siddhi which means an object to attain perfection or heavenly bliss. Health as the perfect state of physical, psychological, social and spiritual component of human being. ❖ The system of medicine has a basic principle of “unave marunthu, marunthe unavu” along with concepts of vali, azhal and iyyam. The siddhars are well versed in preparing the higher level of medicines using ulogangal and kanimangal drugs. These processes of high level medicine to attain high quality through alchemy. For this first they have to purify the raw drug, it not only removes the impurities, but also enhance the property of drugs. Standardization ensures the availability of the uniform product in all part of the world and encourage opportunities for siddha formulations in pharmaceuticals , the present study was carried out with an aim to standardize the purification of indhuppu (sodium chloride impure) based on qualitative and quantitative analysis as per PLIM guidelines. ❖ Purification process of indhuppu is more important to remove toxins, to increase its efficacy and change to easily acceptable form. Sodium chloride impura are traditionally used for laxative property. Its laxative property is superior than cream of tartar. Rock salt also got flatulent, diuretic and appetite stimulant properties. ❖ Rock salt cures eight types of gastric ulcer (gunmam), indigestion, blood diseases, kaphapitha, kapathikkam, nerves syphilis, derangement of three humours, constipation, poisonous bite, spermatorrhoea, head, eye, tongue, tooth, skin, trunk, vagina diseases, delirium, cataract, polydypsia, asthma (dysponea), haemorrhoids, abscess, rat bite, scorpion bite, vatha pain, throbbing pain etc., ❖ Siddha system recommended that before going to every siddha medicine preparation, the ingredient should be purified properly. The concept of suddhi (purification) in siddha is not only a process of purification or detoxification, but also a process to enhance the potency and efficacy of the drug. ❖ The raw material is purchased from raw drug store in Thakalay, then it is splited into two equal halves of 500gm. For purification I choose the method in Gunapadam – Thathu jeeva vaguppu part 2 and 3 by Dr.R.Thiyarajan page no. 370. ❖ For purification, the rock salt is kept soaked in goat‟s urine for 3 naazhigai, and kept in sunlight until it is dried to get the purified form. The qualitative and quantitative analysis were done. ❖ By the pysico chemical analysis of purified indhuppu, the colour and ph was white , 8.70, tha total ash value is 93.45%. ❖ Biochemical analysis of purified indhuppu indicates the presence of calcium, chloride, sulphate, ferrous iron and amino acids. ❖ ICP – OES Analysis of purifed indhuppu indicates the presence of concentration of elements C- 105.210 mg / l, Ca – 00.760 mg / l, Na – 750.200 mg / l, P – 126.300 mg / l, S – 00.334 mg / l, and other elements like As, Cd, Cu, Fe, Hg, K, Mg, Pb and Zn is in below detection level. ❖ The 2Ɵ value of purified indhuppu is 38.30 2Ɵ, 44.42 2Ɵ, 64.40 2Ɵ, 77.45 2Ɵ. ❖ Absence of total bacterial count and the absence of total fungal count is noted in sterility test for purified indhuppu. ❖ The aflatoxin test of purified indhuppu shows that there were no spots were being identified in the test sample loaded on TLC plates when compare to the standard which indicates that the sample were free from Aflatoxin B1, Aflatoxin B2, Aflatoxin G1, Aflatoxin G2. ❖ The FTIR analysis of purified indhuppu shows the presence of alcohol, alkanes, alkenes, aromatic compounds, nitro compounds, alkyl and aryl halides. ❖ Thus it can be postulate that the purification procedures as mentioned in siddha literature help to remove the toxic effect without interfering its therapeutic efficacy. It may reduce the effect of toxic substance in the drug. ❖ The study stresses the need of purification process of the drug before going to preparation of medicines with strong evidence, information obtained from these studies can be used as markers in the identification and standardization of the compound. CONCLUSION: Standardization of siddha medicine is a need to be in the present world, even though our medicine has the efficacy, potential, long back indigenous the quality of a drug should be defined as the status of a drug that is determined by identity, purity, content and other chemical , physical or biological properties here the purification of sodium chloride impura was done. The present study is an attempt to establish the scientific basis of the raw drug. ❖ From the data's of the present investigation it was concluded that the siddha drug indhuppu (sodium chloride impura) was purified and analyzed. There were notable changes found between unpurified and purified form of indhuppu. Hence the concept of purification procedure as mentioned in siddha text provides contemporary evidence with a good scientific background. These explorations will definitely help to set a standard procedure for purification of indhuppu in future.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.321916008 |
| Uncontrolled Keywords: | Standardization, Purification, Indhuppu, Sodium Chloride Impura, Comparative Analysis. |
| Subjects: | AYUSH > Nanju Noolum Maruthuva Neethi Noolum |
| Depositing User: | Subramani R |
| Date Deposited: | 01 May 2023 18:43 |
| Last Modified: | 24 Feb 2024 07:00 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/21231 |
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