Gunapriya, K (2022) A Toxicity study on Kabangusa Chooranam. Masters thesis, Government Siddha Medical College, Palayamkottai.
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Abstract
This research Aim was to Evaluate the Safety Profile of Siddha Drug - “KABANGUSA CHOORANAM” and authenticated siddha referenced medicine obtained from; Chikitsarathina Deepam – part II, First Edition, Vaithiya chindhamani by vaithiya vithvanmani Kannusaami pillai .S, Rathina naayakkar & Son‟s publications (Page No. 166). KBC ingredients were, Purified chukka (35g), Purified Milagu (35g), Purified Thippili (35g), Purified Chittaratai (35g), Purified Akkarakaram (35g), Purified Omam (35g), Purified Desavaram (35g), Purified Kadukkai (35g), Naatu sarkarai (280g). The medicine prepared, as per the method mentioned in the Siddha literature. Indicated for Kapha Rogam (Respiratory diseases). ❖ In review of literature, the ingredients of Kabangusa chooranam were discussed in depth with a special attention paid to their medicinal uses and toxicological aspects. ❖ The prepared medicine KBC characterized as per PLIM guidelines and instrumental analyses. Finally Evaluated the Acute toxic effect of KBC in rats as per OECD 423 guidelines and the Sub-acute toxic effect of KBC in rats as per OECD 407 guidelines. ❖ According to the results and observations of the Acute toxicity study of siddha drug Kabangusa Chooranam (KBC) as LD50 was greater than 2000mg/kg body weight in Wistar Rats. In sub-acute toxicity evaluated Repeated dose 28 days oral toxicity study of Kabangusa Chooranam revealed that the NOAEL (No Observed Adverse Effect Level) of Kabangusa Chooranm should be greater than 1800 mg/Kg b.wt and the drug is safe for human consumption. In Low Dose- 180mg/kg bodyweight was no significant different in any hematological and the gross & histopathology changes therefore clinically safety to oral administration of KBC was (Therapeutic Dose is equal to Low Dose) 180mg/kg body weight in rats in repeated oral dose 28 days period. ❖ KABANGUSA CHOORANAM (KBC) is safety in biological aspect, characteristic way of chemical constituents and toxicological evaluation on Acute & Subacute toxicity study proved as per Siddha Text reference by 180mg/kg body weight as therapeutic dose of mentioned indications. CONCLUSION: From the above discussion following conclusions have been drawn to satisfied the objectives and achieved the research aim through the above results. Kabangusa Chooranam was taken as test drug, prepared using authenticated siddha literature. And it was characterized by Brownish, Very fine, solid state, strongly aromatic, soft, moderately free flowing. The quality parameters and safety profile of the drug were analyzed as per standard protocol. The qualitative and quantitative analysis of Kabangusa chooranam proved the quality and purity of the drug. The quality assessment results will be used as standard for future research on Kabangusa chooranam. According to the Results and observations of toxicity study of Siddha Drug Kabangusa chooranam (KBC), the Acute toxicity study results did not show any mortality, behavioural changes and drug related toxicity. From the Acute toxicity study, it is revealed that KBC is not toxic at a maximum oral dose level of 2000 mg/kg in Wistar rats. So, the median lethal dose (LD50) of KBC is greater than 2000 mg/Kg.b.wt. In Repeated Dose 28 Day oral toxicity study, haematological and biochemical parameters of 1800mg/kg b.wt test drug treated animals were within normal limit and histopathological parameters showed no significant changes in internal organs compared with control group. So, the No Observed Adverse Effect Level (NOAEL) of KBC is greater than 1800mg/kg.b.wt. Hence, the safety of Kabangusa Chooranam is proved through this study. So, the recommended human dose may not produce any ill effects and this must be proved by further clinical trials, Pharmacological studies and efficacy studies. This dissertation work is the first step for continuous research in this title. This research Evaluates the Safety Profile of Siddha Drug “KABANGUSA CHOORANAM” by characterization and toxicological study, which gives preventive, promotive, curative, and rejuvenative health for many diseases in the world.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | Reg.No.321916004 |
| Uncontrolled Keywords: | Kabangusa Chooranam, Toxicity study. |
| Subjects: | AYUSH > Nanju Noolum Maruthuva Neethi Noolum |
| Depositing User: | Subramani R |
| Date Deposited: | 01 May 2023 18:38 |
| Last Modified: | 24 Feb 2024 06:57 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/21227 |
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