Gandhimathi, N (2022) A Toxicity study on Thasadeepakkini Chooranam. Masters thesis, Government Siddha Medical College, Palayamkottai.
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3206 014 22 321916003 Gandhimathi N.pdf Download (16MB) | Preview |
Abstract
The Pre clinical reveals, all animals from control and all the treated dose groups survived throughout the dosing period of 28 days. The results for body weight determination of animals from control and different dose groups show comparable body weight gain throughout the dosing period of 28 days. During dosing period, the quantity of food and water consumed by animals also significantly increase. The results of hematological investigations conducted on day 29th day revealed no significant changes in the hematological values when compared with those of respective controls. This gave clear justification that bone marrow and spleen were not influenced by TDC. The clinical biochemistry analysis was done to evaluate the possible alterations in hepatic and renal functions not influenced by the test drug. Results of Biochemical investigations conducted on days 29 and recorded in revealed the no significant changes in the values of different parameters studied when compared with those of respective controls; Urea, SGOT, SGPT, Bilirubin were within the limits. Group Mean Relative Organ Weights are recorded Comparison of organ weights of treated animals with respective control animals on day 29 was found to be normal comparable with respective control group. CONCLUSION: From the above discussion following conclusion have been drawn to satisfied the objectives and achieved the research aim through the above results. Thasadeepakkini Chooranam was taken as test drug, prepared using authenticated and Siddha literature. And it was characterized by Brownish, very fine, solidstate, pronounced herbal aroma, soft, moderately free flowing. The quality parameters and safety profile of the drug were analyzed as per standard protocol. The qualitative and quantitative analysis of Thasadeepakkini Chooranam proved the quality and purity of the drug. The quality assessment results will be used as standard for future research on Thasadeepakkini Chooranam. According to the results and observations of toxicity study of Thasadeepakkini Chooranam is proved recommended human dose may not produce any ill effects and this must be proved by further clinical trials, pharmacological studies and efficacy studies. This dissertation work is the first step for continuous research in this title. Finally, it assessed the safety of Thasadeepakkini Chooranam [TDC] in standard of siddha drugs by characterization through instrumental analysis and toxicity studies through animal experiments.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.321916003 |
| Uncontrolled Keywords: | Thasadeepakkini Chooranam, Toxicity study. |
| Subjects: | AYUSH > Nanju Noolum Maruthuva Neethi Noolum |
| Depositing User: | Subramani R |
| Date Deposited: | 01 May 2023 18:37 |
| Last Modified: | 24 Feb 2024 06:56 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/21226 |
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