Ananthi, V (2022) A Toxicity study on Manosilai Chooranam. Masters thesis, Government Siddha Medical College, Palayamkottai.
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Abstract
This Research AIM was to evaluate the safety profile of Siddha Drug “Manosilai Chooranam” and authenticated Siddha referenced medicine “Gunapadam Thathu Jeevam" 2 & 3 Page no 352. Preparation ingredients were : Purified Manosilai, Purified Karunjeeragam, Purified Kombarakku, Purified Merugan kizhangu, Purified Kazharchiparuppu, Purified Moongiluppu Dosage 1/4 Varaganedai (1g),Thrice a day and its vehicle/adjuvant : Honey and its indication Natpattasuram (Chronic fever) procured and Authenticated Raw material then, purified and prepare the Manosilai Chooranam (MC) as per the classical way. prepared MC characterized as per PLIM Guidelines and instrumental analyses. Finally evaluated the acute toxicity effect of MC in rats as per OECD 423 Guidelines and the sub acute toxic effect of MC in rats as per OECD 407 Guidelines. According to the results and observations of the toxicity study of Siddha drug Manosilai Chooranam as LD50 was calculated as 2000 mg/kg body weight in wister Rats from acute toxicity study. In Sub acute toxicity evaluated No Observed Adverse Effect Level (NOAEL) in Low Dose 270 mg/kg body weight was no significant different in any heamatological and the gross & histopathology changes there fore clinically safety to oral administration of Manosilai Chooranam (MC) was (Therapeutic Dose is equal to Low dose) 270 mg/kg body weight in rats in repeated oral dose 28 days period. Manosilai Chooranam is safety in biological aspect, characteristic way of chemical constituents and toxicological evaluation on Acute & Sub acute toxicity study proved as per Siddha text references by 1g/kg body weight as therapeutic dose of mentioned indications. CONCLUSION: From the above discussion following conclusion have been drawn to satisfied the objectives and achieved the research aim through the above results. Manosilai Chooranam was taken as test drug, prepared using authenticated Siddha literature and it was characterized by Brownish, very fine, solid state, strongly aromatic, soft, free flowing. The quality parameters and safety profile of the drug were analyzed as per standard protocol. The qualitative and quantitative analysis of Manosilai Chooranam proved the quality and purity of the drug. The quality assessment results will be used as standard for future research on Manosilai Chooranam. According to the results and observations of sub acute toxicity study reveals high dose level of MC there is No significant changes. That is safer Therapeutic dose indicate 1g in Siddha literature. toxicity study of Manosilai Chooranam is proved recommended human dose may not produce any ill effects and this must be proved by further clinical trials. This dissertation work is the first step for continuous research in this title. Finally, it assessed the safety of Manosilai Chooranam [MC] in standard of siddha drugs by characterization through instrumental analysis and toxicity studies through animal experiments.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.321916001 |
| Uncontrolled Keywords: | Manosilai Chooranam, Toxicity study. |
| Subjects: | AYUSH > Nanju Noolum Maruthuva Neethi Noolum |
| Depositing User: | Subramani R |
| Date Deposited: | 01 May 2023 18:36 |
| Last Modified: | 24 Feb 2024 06:55 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/21224 |
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