Sunanna, L (2022) A Prospective Open Labelled Non Randomized Phase II Clinical Trial on Uthiravatha Suronitham with Trial Drug Seenthil Chooranam. Masters thesis, Government Siddha Medical College, Palayamkottai.
Full text not available from this repository.Abstract
A prospective open labeled Phase II, Non- Randomized clinical trial to evaluate the efficacy of the Seenthil Choornam in treating the UTHIRAVATHA SURONITHAM. The study was conducted at Govt.Siddha Medical College & Hospital, Palayamkottai, Tirunelveli. UTHIRAVATHASURONITHAM is one among the 80 Vatha diseases according to Yugi Vaidya Chinthamani-800. It is characterized by bilateral simultaneous involvement of smaller joints of hands and feet, elbow joint, knee and ankle joints and other joints with pain and swelling, in chronic conditions resulting in deformities. There are multisystem involvements, Loco motor system gastrointestinal tract, circulatory system along with psychological disturbances also. Uthiravatha suronitham is compared to Rheumatoid arthritis in modern medicine. Seenthil Choornam is a herbo – animal drug contains, Seenthil, Karisalai and Poonagam and it is mentioned in Siddha literature Agathiyar Paripooranam -400. The collected raw drugs were purified powdered and combined as per the literature. The preclinical evaluations of Seenthil Choornam were conducted- Physicochemical evaluation, Phytochemical evaluation, Anti-oxidant activity evaluation and Antimicrobial activity evaluation. Pharmacological and Toxicity studies were included in the study. The following data were obtained from above study. The females were more prone to this diseases and the age group is mostly between 30 to 50 years i.e. during the Pitha kalam. During Pinpani kalam, Koothir Kalam and Elavenil Kaalam most of the patients have more symptoms. So the drug was administered according to their body constitution and climatic changes for getting better results. The Biochemical evaluation showed the presence of Sulphates, Chlorides and Amino acids. The Phytochemical evaluation showed the presence of Carbohydrates, Proteins, Alkaloids, Flavonoids and Saponin. The Anti-microbial activity study showed that the Aq. Extract of sample –SEC is active against both Gram positive and Gram negative bacteria- Staphylococcusaureus, Enterococcus feacalis, Bacillus Subtilis,Klebsiella Pneumonia, Pseudomonas aeruginosa and fungi-Aspergillus flavus. Anti-oxidant activity assay showed that the drug had very effective free effective free radical scavenging activity against DPPH and thus it has good Anti-oxidant property. The Pharmacological study showed that the drug have very effective Anti-inflammatory, Analgesic and Immunomodulatory activity without making any other ill effects. The toxicity study revealed that the drug dose not producesany toxic effects even in its maximum dose of 2000mg/kg body weight of animal. So it is safe for human administration. The statistical analysis showed that the P Value is less than .5, so, that the Seenthil Choornam have good efficacy in treating Seenthil Choornam.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | Reg.No.321911010 |
| Uncontrolled Keywords: | Prospective Open Labelled Non Randomized Phase II Clinical Trial, Uthiravatha Suronitham, Trial Drug, Seenthil Chooranam. |
| Subjects: | AYUSH > Maruthuvam |
| Depositing User: | Subramani R |
| Date Deposited: | 01 May 2023 18:19 |
| Last Modified: | 05 May 2023 15:46 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/21202 |
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