Morphometric analysis of CD1a positive Langerhans cells in the Human Tympanic Membrane.

Tripti Meriel, Jacob (2006) Morphometric analysis of CD1a positive Langerhans cells in the Human Tympanic Membrane. Masters thesis, Christian Medical College, Vellore.

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Abstract

The immune system consists of lymphoid organs and a heterogeneous group of motile cell types that are involved in the defense of the body against invasion by bacteria, viruses and other foreign bodies. Dendritic cells form a system of antigen presenting cells that is widely distributed in the body. They constitute trace population in lymphoid and nonlymphoid tissues and in the circulation. They are characterized by their typical dendritic and “veiled” morphology, by their constitutive of high levels of major histocompatiblity complex class II molecules on their surface, and their outstanding capacity to initiate primary immune responses. Dendritic cells occur in two states of differentiation. In the immature state they are highly specialized for processing foreign protein antigens; in the mature state, they efficiently stimulate resting antigen- specific T cells. Dendritic cells can migrate from the non-lymphoid tissues, where they reside in immature state, via the afferent lymphatics or blood to the T cell dependent areas of lymphoid organs like lymph nodes and the spleen. There, they appear as mature dendritic cells. Therefore dendritic cells are ideally suited to mediate important aspects of immunogenicity: they can acquire antigens in the tissues and process them in an immunogenic form; they can carry that immunogens to the lymphoid organs; and they can find and efficiently activate antigen-specific T cell clones and thus generate an immune response. Aim: To quantitatively analyze, and to study the distribution and morphology of CD1a positive Langerhans cells in normal cadaveric and diseased human tympanic membrane. Objectives: To confirm the presence of CD1a positive Langerhans cells in normal human tympanic membrane. To study the distribution and morphology of CD1a positive Langerhans cells in normal human tympanic membrane. To study the distribution and morphology of CD1a positive Langerhans cells in tympanic membranes of patients with chronic otitis media of both the tubotympanic and atticoantral varieties. To quantify the number of CD1a positive Langerhans cells in normal versus diseased tympanic membrane. Conclusions: The normal tympanic membrane does contain Langerhans cells distributed through the pars tensa. The mean number of Langerhans cells per unit length of basement membrane in chronic otitis media of the tubotympanic variety is significantly higher than that of the normal tympanic membrane. The mean number of Langerhans cells per unit length of basement membrane in chronic otitis media of the atticoantral variety is significantly higher than that of the normal tympanic membrane and chronic otitis media of the tubotympanic variety. In chronic otitis media of the atticoantral variety, the mean diameter of the cells increases significantly. The mean number of dendritic processes and their length do not increase significantly in chronic otitis media.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Morphometric analysis; CD1a Positive Langerhans cells; Human Tympanic Membrane.
Subjects: MEDICAL > Anatomy
Depositing User: Kambaraman B
Date Deposited: 22 Jun 2017 05:26
Last Modified: 22 Jun 2017 06:27
URI: http://repository-tnmgrmu.ac.in/id/eprint/212

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