Gowsalya, E (2022) Clinical Evaluation of Kagamaasi Thylam (A Siddha Drug) in the Management of Sooli Kanam (Childhood Asthma) in Children. Masters thesis, National Institute of Siddha, Chennai.
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Abstract
This study was started with the aim of treartment and management of Sooli Kanam (childhood asthma) aged from 5 to 12 using Kagamaasi thylam (internal) for 45 days. The study was enrolled in CTRI after the approval of IEC. The participants were recruited after their assent and consent of both child and parent. The medicine was taken twice a day for 45 days. The preclinical study such as physicochemical, biochemical, phytochemical, invitro assay of the trial drug were analysed. The ingredients present in this medicine have anti-asthmatic property. The drug was assessed for anti-inflammatory activity. The trial drug had convincing anti-inflammatory activity by protein denaturation method. The phytochemical analysis of the study revealed the presence of flavonoids, tri terpenoids, phenols and tannin. Biochemical analysis revealed the presence of Iron and Carbonate. The drug was studied for aflatoxin and pesticide residue and was free from toxin hence it is a safe drug to use. There was no traces of heavy metals, it was analysed by atomic absorption spectrometry. The prognosis was assessed using PAS score an d Peak expiratory flow meter rate. The results were statistically analysed and it was significant (<0.0001). So, this trial drug can be used as an anti-asthmatic drug in the treatment and management of Sooli Kanam (childhood asthma) in the age group of 5 to 12. CONCLUSION: Sooli Kanam may be correlated with childhood asthma, which is a very serious global concern. This disease is very active in childhood than in adult stage. It will affect their quality of life in terms of emotional stability, academic performance, and sports achievements. Treating this disease is very essential and also in the right time too. Siddha, a very important branch of traditional system of medicine offers several numbers of medicines to treat all the 4448 diseases. Respiratory disorders are well managed in Siddha system of medicine and it made major impact in public. Kagamaasi thylam from Theraiyar Thylavarga Surukam also done a very efficacious management in treating Soolli Kanam (childhood asthma) among 30 children in 45 days. The participants were mostly relived from the clinical symptoms such as cough, dyspnoea, wheezing. Pediatric Asthma Severity score and Peak Expiratory Flow Rate assessment shows a significant statistical report. Inflammation of airway is the major pathogenesis in asthma. Phytochemical and Invitro analysis proves that the medicine have anti-inflammatory activity. This was limited as Phase II clinical trail, in future this study may conducted as Randomized Clinical Trail.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.321914201 |
| Uncontrolled Keywords: | Clinical Evaluation, Kagamaasi Thylam, Siddha Drug, Management, Sooli Kanam, Childhood Asthma, Children. |
| Subjects: | AYUSH > Kuzhanthai Maruthuvam |
| Depositing User: | Subramani R |
| Date Deposited: | 01 May 2023 16:03 |
| Last Modified: | 23 Feb 2024 08:13 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/21187 |
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