Sindhu, V (2022) Clinical Evaluation of the Effect on Oral Administration of Vatha Karappan Chooranam along with External Administration of Sivappu Ennai in the Management of Vatha Karappan. Masters thesis, Government Siddha Medical College, Palayamkottai.
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Abstract
In this study 44 cases were treated in OPD (24) and IPD (20) oF Postgraduate Kuzhanthai Maruthuvam in GSMC, Palayamkottai. Skin diseases can have a devasting effect on person’s physical and psychological wellbeing. It adversely affect almost every aspect of a person’s life. They can also seriously affect the lives of other family members and caretaker. • The psychological impact of skin diseases on an individual is not directly related to overall area affected or to the objective severity of the condition. However, there is a evedience that suggests being affected in visible places such as face, head, hands or intimate genital areas causes higher level of distress as they are less easily covered and can precipitate or perpectuate relationship issues. • So in the case of Vatha Karappan is a common diseases in pediatric age group. This diseases mostly resembles Exfoliative dermatitis in modern system. Hence I choosen the trial drug Vatha Karappan Chooranam (Internal) and Sivappu Ennai (External) to treat children. The clinical trial was started after Screened by the screening committee and the approval from IEC of GSMC, Palayamkottai, IEC approval no is GSMC/IEC-VII/2020-Br.IV/17-06.11.2020 and it was registered in clinical Trial Registry of India. • After the CTRI Registration, (CTRI/2021/01/030317).First the ingretients of the trial drug was authenticated by the Head of the Department of Gunapadam and then prepared the medicine and was authenticated by Head of the department of Kuzhanthai maruthuvam GSMC, Palayamkottai. • The ingredients of the trial drug contains the taste Sweet (Koogaineer), Bitter (Karungeeragam, Amukkara kizangu, Poothakarappan pattai), Pungent (Vasambu, Elakkay, Kirambu, Jaathipaththiri) astringent (Jaathipaththiri). These tastes reduce the increased Kabam and Vatham thathu in Vatha Karappan and reduce the inflammation of disease The Phytochemical analysis reveals the presence of Sulphate, Chloride, Starch, Ferrous iron, Tannic acid, Unsaturated compound, Amino acid. • The physiochemical analysis reveals loss on drying 105 degree C was 2.5+0.3, total ash value 7.167+2.329, acid insoluble ash 0.023+ 0.015 , water soluble ash 0.023+0.015.The trial drug also free from Heavy metals, Alflatoxin and Pesticide residues. So it is safely given to pediatric patients. • The clinical trial starts mainly after obtaining the approval from the institutional Animal Ethical Committee (IAEC). The approval Number was SARPC/IAEC/28/2021. Anti histamine activity was carried out in Arulmigu Kalasalingam College of Pharmacy College in Krishnankoil. • After completing the above preclinical studies the clinical trial was begun based on inclision and exclusion criteria with 44 patients in my study. The separate proforma was maintained. Vatha Karappan Chooranam was administrated 21 days to the patients who were came with Symptoms of Vatha Karappan. CONCLUSION: Various studies and review were performed for the clinical evaluation of the effect of Vatha Karappan Chooranam and Sivappu Ennai for the treatment of Vatha Karappan. As a result, this clinical study evaluated that over 39 (88.6%) patients shows good improvement, 3 (6.8%) patient shows moderate improvement and 2 (4.5%) patients shows mild improvement. • 39 (88.6%) cases are fully recovered from Vatha Karappan and there is gradual reductions in clinical symptoms and also there is no re-occurrence of the disease during entire course of treatment. It is evident that the trial medicines were effective for the management of Vatha Karappan and also it has no adverse effects. Cost of trial drug was also low and affordable to people. • The Phytochemical and Phytoconstituents present in trial drug relieves the Symptoms of the disease. Emollient action also present in the trial drug. • Analytical specifications of Vatha Karappan Chooranam and Sivappu Ennai and pre clinical studies evident the safety and efficacy of trial drugs. It also assured that it is safe for use for peadiatric age group. • Hence, this study concluded that the Vatha Karappan Chooranam as internal medicine combined with the Sivappu Ennai as external medicine treats Vatha Karappan along with diet restrictions and good hygiene.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.321914007 |
| Uncontrolled Keywords: | Clinical Evaluation, Oral Administration, Vatha Karappan Chooranam, External Administration, Sivappu Ennai, Management, Vatha Karappan. |
| Subjects: | AYUSH > Kuzhanthai Maruthuvam |
| Depositing User: | Subramani R |
| Date Deposited: | 01 May 2023 15:33 |
| Last Modified: | 14 Feb 2024 16:09 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/21178 |
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