Cyclin D1 Expression in Laryngeal Cancer.

Mohan Raj, R (2006) Cyclin D1 Expression in Laryngeal Cancer. Masters thesis, Cancer Institute (WIA), Chennai.


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INTRODUCTION : Laryngeal squamous-cell carcinomas (LSCC) comprise the vast majority (96%) of laryngeal malignancies. Larynx has several clinical and molecular peculiarities. The American Cancer Society classifies the larynx as part of the respiratory system, separate from the oral cavity and pharynx. Most of these tumors originate in the glottis and supra glottis; the sub glottis is an extremely rare site of origin. The estimated incidence of cervical lymph-node metastases with no obvious primary site (occult T) is from 3% to 9% 5, 6 and some of these might reasonably have a laryngeal (especially supra glottic) origin. The male/female ratio for the incidence of laryngeal cancer is much higher than in other parts of the head and neck. Differences in chromosomal pattern and carcinogenic progression between LSCC and other head-and-neck squamous-cell carcinomas (HNSCC) have been detected by comparative genomic studies. The prognostic stratification of LSCC patients is inadequate since similar patients, affected by tumors with similar clinico pathological features and undergoing the same treatment, may differ widely in prognosis, probably due to the extreme biological heterogeneity of LSCC, which contributes to the lack of consistency in treatment planning. So a different approach to LSCC, based on genetics and molecular biology in addition to the clinical and histological approach, is required to overcome these obstacles and to reduce cancer-related mortality in LSCC patients. Systematic study of biological markers might be integrated into clinical practice in the phases of prevention as ‘molecular epidemiology’ of diagnosis as ‘molecular diagnostics’, of prognostic assessment and treatment selection as ‘molecular characterization’, and of the synthesis of new drugs as ‘molecular targeting’. Objectives : 1. To analyze the expression of Cyclin D1 – a cell cycle regulatory protein, in squamous cell carcinoma of larynx patients 2. To correlate the expression of Cyclin D1 with clinical and pathological parameters like Age of the patient, Extent of tumor and Nodal status, Grade and Stage of the tumor, any predilection for sub sites in the larynx. 3. To investigate whether over expression of Cyclin D1 is associated with an increased likelihood of tumor recurrence and over expression of Cyclin D1 could serve to identify a proportionally distinctive group of patients. CONCLUSION : In this study only the Extent of tumor (T status) correlates with the over expression of Cyclin D1. Otherwise this study did not support the hypothesis that Cyclin D1 over expression is an independent significant predictor for Stage of disease, Nodal status, Grade of tumor or Recurrence of disease. Possibly Cyclin D1 gene amplification may be better prognosticator than it’s protein over expression as studied by Bellacosa, Kyomoto, Distinct molecular pathways at different anatomical regions involved, not only in the abnormal function of the Cyclin D1 cell cycle regulator, but also in the development of tumors without Cyclin D1 alteration. Discovery Today: Disease

Item Type: Thesis (Masters)
Uncontrolled Keywords: Cyclin D1 Expression ; Laryngeal Cancer.
Subjects: MEDICAL > Surgical Oncology
Depositing User: Kambaraman B
Date Deposited: 26 Jul 2017 02:31
Last Modified: 26 Jul 2017 02:31

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