Jeeva, S (2022) Standardization and Pharmacological screening of Anti-Ulcer, Anti-Spasmodic, and Haematinic Activites of Siddha Formulation of Lavana Dravagam (LD). Masters thesis, National Institute of Siddha, Chennai.
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Abstract
It was indicated for Lavana Dravagam mentioned in Siddha text Kannusamiyam ennum vaithiya segaram , page no 158 has been used for Gunmam (ulcer), Pandu (Anaemia), Soothagakkatty (Polypus uteri, internal abscess), Surakkatty (enlargement of spleen) Hence, it is studied for Anti-Ulcer, Hematanic activity and Anti Spasmodic activity in animal models. The literature for the ingredients of drug was done in order to reveal the uniqueness of drug. It was carried out in three aspect. Siddha aspect and Mineralogical aspect and Chemical aspect. After literature review, the drug was exposed to standardization. As a preliminary step, the drug was subjected to Physicochemical and Biochemical analysis, FTIR and Instrumental analysis was done by ICP – OES. After collecting adequate data on standardization of the drug, it was subjected to acute toxi evaluation to ensure safety of the drug. It was done by following OECD guidelines 423 (Acute Oral Toxicity). After assuring the safety of test drug, pharmacological studies were carried out for Anti-Ulcer activity, Hematinic activity and Anti-Spasmodic activity in animal models to explore its therapeutic efficacy. The results of these study showed that the test drug has potent activity against anemia gatric ulcer and spasmodic pain. Thus, the drug Lavana Dravagam (LD) has significant medicinal values and it can be a very good drug of choice for proceeding with clinical trials in future. CONCLUSION: From the literature evidence, Biochemical analysis, Acute Toxi evaluation and Pharmacological studies, the drug Lavana Drvagam has Antiulcer, anti- spasmodic and Hematinic activity. It is concluded that the drug Lavana Dravagam can be used in the management of Gunmam (peptic ulcer) and Pandu anemia. Lavana Dravagam is a poly mineral siddha formulation obtained by distillation process as mentioned in the text named kannusay ennum vaithiya segaram. Based on the above studies, it is evident that the drug Lavana Dravagam is safe and therapeutically effective. Further clinical studies can be done to bring it as effective drug for diseases of Pandu (anemia) and Gunmam (gastric ulcer).
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.321912203 |
| Uncontrolled Keywords: | Standardization, Pharmacological screening, Anti-Ulcer, Anti Spasmodic, and Haematinic Activites, Siddha Formulation, Lavana Dravagam (LD). |
| Subjects: | AYUSH > Gunapadam |
| Depositing User: | Subramani R |
| Date Deposited: | 01 May 2023 14:10 |
| Last Modified: | 14 Feb 2024 15:03 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/21166 |
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