Anandhakrishnan, M (2022) Safety and Pharmacological Evaluation of Anti-ulcer, Anti-pyretic and Anti-spasmodic Activities of Dhasalavana Dravagam. Masters thesis, National Institute of Siddha, Chennai.
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Abstract
Dhasalavana Dravagam, is a distillate drug comprising of minerals. It was indicated for Vayiru vali (Spasmodic pain), Soolai (Stabbing pain) Kunmam (Acid peptic disease), Aseeranam (Indigestion), Maarbu vali (Chest pain), Vaanthi (Vomiting), Soothagavayu (Dysmenorrhea), Suram (Pyrexia), Sura katti (Hepatomegaly, Splenomegaly). Hence, it was studied for Anti-Ulcer, Anti-pyretic and Anti Spasmodic activity in animal models. ❖ The review of literature for the ingredients of drug was done in order to reveal the uniqueness of drug. It was carried out in two aspects viz, Siddha aspect (to know the details given in old siddha literatures) and Chemical aspect (to know its chemical properties and reactivity). After literature review, the drug was exposed to standardization. As a preliminary step, the drug was subjected to Physicochemical and Biochemical analysis, Instrumental analysis was done by ICP – OES. ❖ After collecting adequate data on standardization of the drug, it was subjected to toxicological evaluation to ensure the safety of the drug. It was done by following OECD guidelines 423 (Acute Oral Toxicity). The results of the toxicity study indicated that the drug is nontoxic and it will not produce any toxic signs on human beings. ❖ After assuring the safety of test drug, pharmacological studies were carried out for Anti-Ulcer activity, Anti-pyretic and Anti-Spasmodic activity in animal models to explore its therapeutic efficacy. The results of these study showed that the test drug has potent activity against pyrexia and gastro intestinal disorders. Thus, the drug Dhasalavana Dravagam has significant medicinal values and it can be a good drug of choice for proceeding with clinical trials in future. CONCLUSION: Dhasalavana Dravagam is a Siddha formulation prepared by distillation process as mentioned in the text named Kannusamiyam ennum vaithiya sekaram. The drug was agreeably standardized and characterized as per the AYUSH guidelines mentioned by Pharmacopoeial Labarotary of Indian Medicines. The safety of the drug was ensured by conducting Acute toxicity study in animal model based on OECD guidelines 423.Then the drug was evaluated pharmacologically for Anti-Ulcer, Anti-pyretic and Anti-Spasmodic activities to ensure the efficacy. Based on the above studies, it is evident that the drug Dhasalavana Dravagam is safe and therapeutically effective. Further clinical studies can be done to bring it as effective drug for treatment of pyrexia and gastro intestinal illness.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | Reg.No.321912201 |
| Uncontrolled Keywords: | Safety and Pharmacological Evaluation, Anti-ulcer, Anti-pyretic and Anti-spasmodic Activities, Dhasalavana Dravagam. |
| Subjects: | AYUSH > Gunapadam |
| Depositing User: | Subramani R |
| Date Deposited: | 01 May 2023 14:00 |
| Last Modified: | 14 Feb 2024 15:01 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/21164 |
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