Correlation between Cyclin D1 expression and Clinical behaviour in Squamous Cell Carcinoma of the Penis.

Rajkumar, P (2006) Correlation between Cyclin D1 expression and Clinical behaviour in Squamous Cell Carcinoma of the Penis. Masters thesis, Cancer Institute (WIA), Chennai.


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INTRODUCTION : Penile cancers are uncommon genitourinary malignancies in the western countries. In Europe, the incidence is 0.1-0.9 per 100,000, and in the USA, 0.7-0.9 per 100,000. In some areas of Asia, Africa and South America, the incidence is significantly higher at 19 per 100.000 in these countries, penile carcinoma accounts for as many as 10-20% of male cancers. This high incidence is related to the poor personal hygiene, socioeconomic conditions and the high prevalence of human Papilloma viruses. In the Madras Metropolitan Tumor registry there were 98 cases reported between 1999 and 2001 for an average total mid year male population of 2,178,842 of which there were 1,643,901 men of 15 – 70 years age group. The crude incidence is 1.5per 100,000 population. The incidence remains stable in most of the western countries, however there is a trend towards a decrease in the incidence in our country due to the improvement in the personal hygiene and socioeconomic status. Penile cancers are generally slow growing tumors with predictable orderly spread to the superficial and deep inguinal and to the pelvic nodes. Distant metastases at presentation are rare. These cancers have a spectrum of presentation with indolent slow growing lesions to highly aggressive metastatic disease. The survival drops drastically when the patient develops nodal metastases. At present there are few clinical or pathological markers which would predict the aggressiveness of these tumors. No definite molecular marker has been identified to predict the aggressiveness. AIM : To find a molecular marker that would predict the clinical behaviour of the local aggressiveness and their metastatic potential. CYCLIN D1 is a molecular marker that is over expressed in most of the epithelial cancer .So for there are only few studies reporting their significance in penile cancers. From our study we tried to correlate their expression with their clinical behavior. CONCLUSION : Cyclin d1 is over expressed in penile cancers. High grade squamous cell carcinomas over express cyclin D1, which is statistically significant. Even though cyclin D1 expression in recurrent tumors is not statistically significant, there is a trend towards over expression in recurrent tumors. Cyclin D1 expression does not show any correlation with ‘t’ status and ‘n’ status.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Cyclin D1 expression ; Clinical behaviour ; Squamous Cell Carcinoma ; Penis.
Subjects: MEDICAL > Surgical Oncology
Depositing User: Kambaraman B
Date Deposited: 26 Jul 2017 02:32
Last Modified: 26 Jul 2017 02:32

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