Gopu, G (2009) A Comparative study of Scrape cytology and biopsy in Mucocutaneous malignancies. Masters thesis, Kilpauk Medical College, Chennai.
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Abstract
INTRODUCTION : Exfoliative cytology is the microscopic examination of shed or desquamated cells from the epithelial surface usually the mucous membrane. It also includes the study of those cells that have been collected by scraping the tissue surface or collected from body fluids such as sputum. The understanding and application of exfoliative cytology techniques in mucocutaneous malignancies in India is not widely used particularly, for the purpose of diagnosis unlike our counter parts in the developed countries. More papers on exfoliative cytology were published during the period 1955-75 than in any other period. Renewed interest emerged in the past decade after the employment of newer techniques of quantitative analysis, DNA cytomorphometry, and identification of tumour markers on the cytological samples. The Rationale of exfoliative cytology lies in the epithelial physiology. Continuous exfoliation of epithelial cells is a part of physiological turnover. Deeper cells, which are strongly adhered in normal conditions, become loose in the case of malignancy and exfoliate along with superficial cells. AIM : Scrape (exfoliative) cytology is a simple and non invasive procedure, which has been a controversial technique according to its real validity. In recent times it has re-emerged due to its application in mucocutaneous cancer as a diagnostic and predictive method as well as for monitoring patients. New diagnostic techniques have been developed, such as “brush biopsy” and multiple molecular studies using the cells collected. The aim of the present study is to compare the usefulness of scrape cytology and biopsy in the diagnosis of accessible mucocutaneous malignancies done at Surgical Oncology department of Government Royapettah hospital and there by determining its sensitivity, specificity, positive and negative predictive value. CONCLUSION : Biopsy is the Gold Standard procedure for the diagnosis of mucocutaneous malignancies. Scrape (exfoliative) cytology is a simple and noninvasive procedure, which has been a controversial technique according to its real validity. In recent times it has re-emerged due to its application in mucocutaneous cancer as a diagnostic and predictive method as well as for monitoring patients. Rationale of exfoliative cytology lies in loss of cohesiveness of cells, proliferating cells and proplastic cells (Cell with an increased activity). The results of the current study demonstrate that scrape cytology is a reliable rapid screening and diagnostic procedure in the outpatient setting for mucocutaneous malignancy. The duration of the scrape cytology process takes 20 min as against 3 to 4 days for biopsy. It is a painless, bloodless noninvasive, quick and simple procedure. In our study the Sensitivity is 70.3% and positive predictive value is 94.8% as against 95% and 98% respectively in other studies.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Scrape cytology ; biopsy ; Mucocutaneous malignancies ; Comparative study. |
| Subjects: | MEDICAL > Surgical Oncology |
| Depositing User: | Kambaraman B |
| Date Deposited: | 25 Jul 2017 03:33 |
| Last Modified: | 25 Jul 2017 03:33 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2110 |
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