Evaluation of Clinical Efficacy of Urai Mathirai as Immuno Modulator

Sathiya Rajeswaran, P (2022) Evaluation of Clinical Efficacy of Urai Mathirai as Immuno Modulator. Doctoral thesis, The Tamil Nadu Dr. M.G.R. Medical University, Chennai.

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The question of efficacy of Urai Mathirai as Immunomodulator and its usage to children was tested with a Null hypothesis that Urai Mathirai is not beneficial as an Immunomodulator. To test this Urai Mathirai was prepared meticulously as per Hospital pharmacopeia of Indian medicine. However, the Bullet shaped rubbing pills were replaced with 50mg tablets as per specific SOP. The tablet matched with the standards prescribed by PLIM and also other parameters for tablets. While preparing all the drugs were authenticated. Pharmacognosy, Physico chemical and phytochemical testing was done as per guidelines. The results revealed the purity of the drug as it is free from heavy metals, Aflatoxins, and Microbial load. In vitro studies for Antioxidant, Anti- Inflammatory and Immunomodulatory effects proved the basic claim of the drug and anti-microbial activity proved the efficacy of drug against certain bacteria. In vivo Safety and Pharmacological studies revealed Nontoxic nature and effectiveness of drug. Anti-inflammatory analgesic and Immunomodulator activity of the drug reassured its traditional claim. Clinical trial carried out helped in proving the efficacy of Urai Mathirai on par with the official siddha formulation Thaleesathi chooranam in controlling repeated respiratory infections. The outcome measures clearly assured the efficacy of Urai Mathirai and proved that Urai Mathirai decreases the disease burden. Four main variables tested helps in proving the claim of the drug’s use in Mantham, Kanam and Loss of appetite. CONCLUSION: Its concluded that preclinical and clinical studies carried over prove that Urai Mathirai possess immuno modulator activity evinced through in vivo Immunomodulatory studies and also by reduction in repeated respiratory infections and disease burden reduction in Clinical trials. RECOMMENDATIONS: • Chronic toxicity study is the limitation and is to be carried out. • Large sample randomized and Blinded trials will help to mainstream this drug. • The efficacy of Urai Mathirai in Bronchial asthma and COPD is to be evaluated.

Item Type: Thesis (Doctoral)
Additional Information: 30184/2011
Subjects: AYUSH > Kuzhanthai Maruthuvam
Depositing User: Subramani R
Date Deposited: 25 Dec 2022 14:55
Last Modified: 19 Jan 2023 02:01
URI: http://repository-tnmgrmu.ac.in/id/eprint/21065

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