Boonesh, H (2021) Protective Role of Naga Parpam – A Zinc Based Herbo-Mineral Formulation against Monocrotophos Induced Fertility Changes in Male Wistar Rats. Masters thesis, College of Pharmacy, Madras Medical College, Chennai.
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Abstract
Naga Parpam has been chosen as the drug to perform the research on its anti-infertility action based on the literature review. Naga parpam which was prepared by repeated calcination of Zinc metal in presence of Eclipta prostrata juice leads to detoxification of metal and size reduction to nanoparticles. Zinc plays a very important role in human body. Zinc has only single oxidation state i.e. Zn2+ and it is found in more than 300 enzymes, present in all six classes of enzymes characterized by the International Union of Biochemistry and required for their catalytic activity. Zn is an important trace mineral that people need to stay healthy. This element is second only to iron in its concentration in the body. Zn is found in cells throughout the body. Zn is involved in numerous aspects of cellular metabolism. Further, Zn is essential for genetic stability and function. This indicates that if Zn is substituted by normal means, which is not in the nano scale, there will be further accumulation in the blood plasma, and it cannot penetrate the cell. If Zn has to be supplied to the cells, which are deficient in Zn, Zn has to be given in a form, which is nontoxic and also it has to penetrate the cells. Hence, Zn should be substituted as nano particle, so that it penetrates the cell. Hence, Naga Parpam is considered for this study. This study concluded that the preliminary classical organoleptic analysis of Naga parpam indicated that it complied with all the classical properties of parapm (i.e lustreless, tasteless, odourless etc). This study concluded that the preliminary physicochemical analysis of Naga parpam indicated that it was alkaline in nature and had high percentage of total ash value (i.e presence of high inorganic content). The phytochemical analysis of Naga parpam indicated the absence of bioactive organic compounds and the chemical analysis revealed that it contains zinc which was thought to be responsible for its protecting role against MCP induced fertility changes. In vitro Antioxidant activity of Naga parpam was evaluated by DPPH free radical scavenging assay and Hydrogen peroxide radical scavenging assay. Results showed that Naga parpam had good anti-oxidant potential.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 261926053 |
| Uncontrolled Keywords: | Protective Role, Naga Parpam, Zinc Based Herbo-Mineral Formulation, Monocrotophos Induced Fertility Changes, Male Wistar Rats. |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Subramani R |
| Date Deposited: | 03 Dec 2022 13:54 |
| Last Modified: | 03 Dec 2022 13:54 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/21035 |
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