Jeevitha, A (2021) Regulation of Lipid, Glucose Metabolism and Insulin Resistance through PPAR using Baicalin. Masters thesis, PSG College of Pharmacy, Coimbatore.
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Abstract
The present study proved that high fructose diet-streptozotocin (40mg/kg/i.p) produces diabetes via insulin resistance and it shows changes in animal body weight and random blood glucose level, insulin sensitivity and also causes alterations in serum lipid levels and histology of liver and pancreas. Thereby Baicalin treatment showed favourable effects on diabetic rats. This study proved the regulative effect of Baicalin on lipid glucose metabolism and insulin resistance in diabetes induced animals which may be due to Pan PPAR agonist activity of the compound. This may be a promising source for the discovery of novel antidiabetic agents. Further studies are needed to explore the safety and molecular mechanisms in the treatment of diabetes mellitus.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 261925906 |
| Uncontrolled Keywords: | Regulation, Lipid, Glucose Metabolism, Insulin Resistance, Peroxisome Proliferator Activated Receptor (PPAR), Baicalin. |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Subramani R |
| Date Deposited: | 03 Dec 2022 13:19 |
| Last Modified: | 03 Dec 2022 13:19 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/21029 |
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