Sakthisundaram, S (2021) Effect of L-Linalool on Primary Symptoms against Reserpine Induced Parkinson’s Disorder in Wistar Albino Rat Models. Masters thesis, Nandha College of Pharmacy, Erode.
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Abstract
Majority of the Central nervous system diseases are life threatening. When there is are cognition of the sign and symptoms of this disease it will help the patient to acquire instant treatment and which will lead to recovery easily and faster. Many neurodegenerative diseases- including amyotrophic lateral sclerosis, Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease- occur as a result of neurodegenerative processes. Parkinson’s disease is the second most common neurodegenerative disease and manifests as bradykinesia, rigidity, resting, tremor and posture instability. Parkinson’s disease is a degenerative disorder of the central nervous system. It results from the death of dopamine- generating cells in the substantia nigra, a region of the midbrain; the cause of cell death is unknown. L-Linalool was used in this research work as the test compound against the treatment of Parkinson. It was analyzed using the In-vivo reserpine induced Parkinson in rat. The effect of L-Linalool were evaluated with different behavioral and biochemical parameter. L-linalool at the dose of (25 and 50 mg/kg, p.o.) produced a significant reduction of tremor in rats, which is induced by reserpine L-linalool was also able to increase the locomotor activity and grip strength in rats. Reserpine induced motor defect was significantly reversed by L-linalool. Amelioration of symptoms of reserpine by L-linalool demonstrates its Anti-Parkinson’s activity. L-linalool showed the antidepressant effect which was found by using swimming test. L-linalool at the dose of (25 and 50 mg/kg, p.o.) produced a significant reduction of depression in rat. Biochemical estimation of dopamine, 3, 4-Dihydroxyphenylacetic acid (DOPAC) homovanillic acid (HVA), showed Linalool at a dose (25 and 50 mg/kg, p.o.) significantly increased the level of dopamine. Above behavioral and biochemical study showed the effect of L-Linalool on treatment of primary symptoms of Parkinson. And it proves to improve the dopamine level in the striatum. CONCLUSION: Parkinson disease is a chronic, progressive, neurodegenerative disorder with multiple pharmacological treatments. The drugs employed clinically in treatment and management of Parkinson was associated with multiple other adverse effect which additionally make its treatment more difficult thus this research was aimed at examining L-Linalool a natural constituent in the treatment of Parkinson and open new vistas in treatment and management of this disease. So, the results indicated the protective effect of L-Linalool against Parkinson disease induced by reserpine model test of wistar rats. The drug can therefore offer an alternative approach in Parkinson state. Conclusively additional investigation is required on other animal models to obtain a dependable oversight of the outcome of L-Linalool on Parkinson in actual clinical scenario.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 261925402 |
| Uncontrolled Keywords: | L-Linalool, Primary Symptoms, Reserpine Induced Parkinson’s Disorder, Wistar Albino Rat Models. |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Subramani R |
| Date Deposited: | 03 Dec 2022 13:01 |
| Last Modified: | 03 Dec 2022 13:01 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/21025 |
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