Mahalakshmi, R (2021) Anti-Psoriatic Effect of Zingiber Officinale Roscae Gel on UV-Radiation and 5% w/w Imiquimod Cream Induced Psoriasis in Wistar Rats. Masters thesis, C.L. Baid Metha College of Pharmacy, Chennai.
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Abstract
Psoriasis is a chronic, non-communicable, painful, disfiguring and disabling disease for which there is no cure and with great negative impact on patients’ quality of life (QoL). It can occur at any age, and is most common in the age group 50–69. The reported prevalence of Psoriasis in countries ranges between 0.09% and 11.4%, making Psoriasis a serious global problem. The Etiology of Psoriasis remains unclear, although there is evidence for genetic predisposition. The role of the immune system in Psoriasis causation is also a major topic of research. Psoriasis occurs worldwide. It affects men and women of all ages, regardless of ethnic origin, in all countries. Data on the prevalence of psoriasis in countries vary between 0.09% and 11.4%. In most developed countries, prevalence is between 1.5 and 5%. There is also evidence to suggest that the prevalence of psoriasis may be increasing. The pathophysiology of Psoriasis is not completely understood. It involves multiple factors, including genetic, immunologic, environmental, stress factors contributing to the development of disease. Cytokines are locally acting protein mediators that are involved in almost all the biological processes including cell growth, activation, inflammation, immunity, and differentiation. Activated T cells are the primary modulators in the pathogenesis of Psoriasis. Disordered cellular immunity involving inflammatory cytokines IL-1 (interleukin-1), IL-6, TNF-α (Tumour necrosis factor) and pro-inflammatory transcription factor has been implicated. CONCLUSION: It may be Concluded that Ethanolic extract of ZOR gel showed Reduction of the Scoring Index (Severity score) such as Scaling, Lesions, Redness, Erythema and decrease in Interleukin-23 in the skin of UV-Radiation induced Psoriasis model. Histopathological study of the skin showed Normal architecture with reduction in Hyperkeratosis, Parakeratosis, and Acanthosis. Increase in Body weight of Imiquimod cream 5%w/w induced Psoriasis model. Histopathological study of the Ear showed Normal architecture with reduction in Epidermal proliferation, Abnormal differentiation, Epidermal accumulation of neutrophils in microabcesses, Neoangiogenesis. Clobetasol propionate cream 0.05% w/w and Tretinoin gel 0.04%w/w act by inhibiting the synthesis of Inflammatory mediator Interleukin-23. ZOR gel also act by inhibiting the synthesis of Inflammatory mediator Interleukin-23 thus, it may be concluded that ZOR gel has significant Anti-Psoriatic activity. Anti-psoriatic activity was found significant in Zingiber officinale roscae may be due to the presence of Vitamin A Beta-Carotene. Further studies to isolate the Chemical constituents responsible for the Anti-Psoriatic activity is required.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 261925005 |
| Uncontrolled Keywords: | Anti-Psoriatic Effect, Zingiber Officinale Roscae Gel, UV-Radiation, 5% w/w Imiquimod Cream Induced Psoriasis, Wistar Rats. |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Subramani R |
| Date Deposited: | 03 Dec 2022 08:54 |
| Last Modified: | 03 Dec 2022 08:54 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/21009 |
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