Vikram, Kudumula (2011) Design and Evaluation of Controlled Release Formulations of Ibuprofen Tablet. Masters thesis, K K College of Pharmacy, Chennai.
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Abstract
Therapeutic efficacy and safety of drugs, administrated by conventional methods, can be improved by more precise spatial and temporal placement within the body, thereby reducing both the size and number of doses by using controlled drug delivery system. An ideal controlled drug delivery system is the one which delivers the drug at predetermined rate, locally or systemically for a specified period of time. An ideal targeted drug delivery system delivers the drug only to its site of action. An ideal drug delivery system should deliver the drug at a rate dictated by the needs of the body over the period of treatment channel the active entity solely to the site of action. To make it in practice various controlled and targeted drug delivery system are introduced. Controlled delivery of drugs, proteins and other bioactive agents can be achieved by incorporating them either in dissolved or dispersed form in polymers. In general controlled delivery attempts to, Sustain drug action at a predetermined rate by maintaining a relatively constant, effective drug level in the body with concomitant minimization of undesirable side effects associated with a saw tooth kinetic pattern. Localize drug action by spatial placement of a controlled release system (rate controlled) adjacent to or in the diseased tissue or organ. Target drug action by using carriers to deliver drugs to particular target cell type. Oral controlled drug delivery system is perhaps the relatively very advanced, newer area of research of its kind. This state-of-the-art formulation development offers several benefits like increased therapeutic efficacy, decreased side effects etc. Biocompatible and biodegradable xanthum gum, glyceryl behanate and stearic acid were experimented with ibuprofen which has served as a model drug for development of controlled release oral tablet. Oral control tablet of ibuprofen with very good physical characteristics were developed. The method of preparation of tablet of ibuprofen was found to be simple and reproducible. The sustained release of ibuprofen from the development oral tablet will help to improve the therapeutic efficacy and patient compliance by reducing the dose and frequency of dosing of ibuprofen perhaps as in vitro dissolution study suggested only 74 % (F2) release of drug over 24 h period. This work shows that stearic acid loaded tablet of ibuprofen could be oral control drug delivery system for ibuprofen for prolonged release. Thus concluding control release tablet of ibuprofen could improve upon physicochemical and biological properties of ibuprofen.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Design and Evaluation; Controlled Release; Formulations; Ibuprofen Tablet |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 22 Jun 2017 04:47 |
| Last Modified: | 22 Jun 2017 06:38 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/210 |
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