Srinivasan, C (2021) Clinical Evaluation of Vallarai Nei (Internal) and Sembarithipoo Ennai (External) for the Management of Kalanjaga Padai (Psoriasis) in Children. Masters thesis, National Institute of Siddha, Chennai.
Full text not available from this repository.Abstract
The study aimed to evaluate the therapeutic efficacy of the Vallarai Nei (internal) and Sembarithipoo ennai (External) for The Management of Kalanjagapadai (Psoriasis) in Children. • Before initiating the clinical trial, approval has gotten from the Institutional Ethical Committee of the National Institute of Siddha NIS/IEC/2019/D-29 & 13-09-2019 for conducting the clinical studies respectively by submitting the well-defined protocol proforma. • The trial was registered prospectively in the Clinical Trial Registry of India and the number: CTRI/2020/06/026154 (Registered on date 26/06/2020). • The raw drugs were authenticated by the Assistant professor of medicinal botany,NIS. • The trial drug was prepared in the Gunapadam lab of the National Institute of Siddha as per the standard operating procedure in the protocol. • As per Siddha Materia Medica, the trial drug's ingredients have found to possess anti-psoriatic, anti-inflammatory, immunomodulator and anti-pruritic activities that might have a significant role in treating Kalanjagapadai. • The Chemical, physicochemical, Phytochemical, HPTLC, heavy metal analysis, pesticide control, Aflatoxin of the trial drug have been carried out. • Out of 50 cases, 30 cases were recruited for the clinical trial. Both Siddha and modern methodology made a clinical diagnosis of Kalanjagapadai. Before initiating the clinical trial, informed consent was obtained from all the patients. • All the patients were advised to for oil bath with Arakku oil on Day -1 and Day-2 they were given purgation with Meganathakuligai100mg with Hot water, Day-3 patients were advised to take rest, no medicine was given on that day to correct the elevated mukkutram. • From Day-4 onwards,Patient have treated for 45 days with Vallarai Nei-5 ml (internal) and Sembarithipoo ennai-50 ml (External). • During each visit in OPD patients (7 days once), clinical assessment was done and the data was noted in the prescribed proforma. • Diet restriction was strictly followed during the period of drug administration as well in the dietary advice form • During the study period, no adverse reactions was reported due to the drug or disease. • The prognosis was assessed clinical assessment done on initial day and the end of the 46th day. The prognosis has recorded through PASI Score. • The outcome has clinically observed by PASI score, that was among 30 Children, 80% (24) were shown Good and 13% (4) shown moderate improvement and 7% (2) were shown mild improvement. • Statistical analysis was done for PASI Score, before and after treatment has been Significantly reduced. (p= 0.0001) • Stress has been relieved by reducing the lesions, itching and scaling. Academic performance has improved. CONCLUSION: From this study, Vallarai Nei (internal) and Sembarithipoo Ennai (External) is safe, efficacious and cost-effective, potent herbal drug in the treatment of KalanjagaPadai (Psoriasis). ➢ The ingredients of Vallarai Nei and Sembarithipoo Ennai has Antipsoriatic, Anti-inflammatory, Anti pruritic activity and Immunomodulator activity. ➢ The PASI score concluded, that was among 30 Children, 80% (24) were shown Good and 13% (4) shown moderate improvement and 7% (2) were shown mild improvement. ➢ Statistical analysis was done for PASI Score, before and after treatment has been Significantly reduced. (p= 0.0001).Therefore the trial drug Vallarai Nei is clinically effective. ➢ There was no adverse reaction reported during the trial period. ➢ The study maybe further carried out with the same drug “Vallarai Nei” and “Sembarithipoo Ennai” in a larger clinical population because of the favourable clinical outcome.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 321814205 |
| Uncontrolled Keywords: | Clinical Evaluation, Vallarai Nei, Sembarithipoo Ennai, Management, Kalanjaga Padai, Psoriasis, Children. |
| Subjects: | AYUSH > Kuzhanthai Maruthuvam |
| Depositing User: | Subramani R |
| Date Deposited: | 17 Nov 2022 16:04 |
| Last Modified: | 17 Nov 2022 16:04 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20977 |
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