Gnanasekaran, S (2019) Evaluation of In Vitro and In Vivo Anti Urolithiatic Activity of Justicia Tranquebariensis on Male Wistar Rats. Masters thesis, College of Pharmacology, Madras Medical College, Chennai.
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Abstract
From the present study we conclude that the preliminary phytochemical analysis of Justicia tranquebariensis. indicated the presence of Flavonoids, quinones, glycosides, coumarins and steroids. ➢ In-vitro Calcium oxalate crystallization inhibition study was evaluated. From this study conclude that the ethanol, ethyl acetate, and hexane extracts of Justicia tranquebariensis. inhibits the calcium oxalate crystallization in the order of 58%, 46% and 39% respectively. ➢ In-vitro turbidity method was evaluated. From this study conclude that the ethanol, ethyl acetate, and hexane extracts of Justicia tranquebariensis. inhibits the calcium oxalate nucleation in the order of 73%, 62% and 61% respectively. ➢ Among the various extracts, the ethanolic extract produce more potent anti urolithiatic activity. ➢ In In-vivo Anti urolithiatic activity of ethanolic extract of Justicia tranquebariensis. was evaluated and we conclude that ethanolicextracts of the plant Justicia tranquebariensis. produced significant antiurolithiatic activity like that of standard. ➢ In the present study provided basic evidence that the justicia tranquebariensis has the beneficial effect for the treatment of urolithiasis. ➢ Further studies are required to elucidate the molecular mechanism of action and its therapeutic potential in the treatment of urolithiasis.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 261726054 |
| Uncontrolled Keywords: | Evaluation, In Vitro, In Vivo, Anti Urolithiatic Activity, Justicia Tranquebariensis, Male Wistar Rats. |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Thavamani K |
| Date Deposited: | 28 Mar 2022 11:37 |
| Last Modified: | 28 Mar 2022 11:37 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2094 |
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