Synthesis, Characterization and Pharmacological Screening of Substituted Benzimidazole

Haritha, P (2021) Synthesis, Characterization and Pharmacological Screening of Substituted Benzimidazole. Masters thesis, Nandha College of Pharmacy, Erode.


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Synthesis of benzimidazole was done from the condensation of O-phenylenediamine and phthalic acid. Benzohydrazide benzimidazole was synthesized by the substitution of hydrazine compounds at 2nd position benzoic acid of benzimidazole followed by the mannich formation at 1st position of benzimidazole. Characterization of compounds were studied by its physical, chemical properties and the spectral interpretation by IR, NMR and Mass spectrums. Substituted Benzimidazoles were subjected to pharmacological screening of analgesic and anti-inflammatory properties. It was concluded that from the synthesized substituted benzimidazoles, most of the compounds shows better response to targeted studies. Further this study may be continued for further substitution to make new moieties and will be focused to study the pharmacological screening like anti-microbial, diabetic activities.

Item Type: Thesis (Masters)
Additional Information: 261915402
Uncontrolled Keywords: Synthesis, Characterization, Pharmacological Screening, Substituted Benzimidazole.
Subjects: PHARMACY > Pharmaceutical Chemistry
Depositing User: Subramani R
Date Deposited: 02 Nov 2022 17:38
Last Modified: 03 Nov 2022 13:51

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