Design, Synthesis, Characterization and Insilico Evaluation of Novel Flavone Derivatives as Anticancer Agents

Mani Megalai, V (2021) Design, Synthesis, Characterization and Insilico Evaluation of Novel Flavone Derivatives as Anticancer Agents. Masters thesis, C. L. Baid Metha College of Pharmacy, Chennai.


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The present study involves the synthesis, characterization and biological evaluation of Claisen Schmidt condensation of indole-3-carboxaldehyde flavone were synthesized based on Magdy A H Zahran et al method. ❖ All the synthesized compounds of present study were characterized and confirmed by IR, and Mass spectral data. It showed characteristic absorption bands and characteristic peaks. ❖ The newly synthesized substituted indole-3-carboxaldehyde flavone derivatives were subjected to preliminary Insilco pharmacological screening. ❖ From the docking results, compounds with good docking score have been synthesized, characterized and subjected to anticancer activity. The results of anticancer study explain that the synthesized active compound could serve as intermediate for generating good biological agents. ❖ Anti-cancer studies were performed for two synthesized compounds (5h and 5k) against EGFR Kinase. The half maximal inhibitory concentration (IC50) of synthesized compounds against breast cancer cell lines (MCF-7) were determined. ❖ Anti-cancer activity of synthesized compounds was tested against MCF-7 cell lines. The compounds 5h exhibited good anticancer activity with the IC50 value ranging in 9.30 ± 0.625 when compared to standard cisplatin was found to 8 ± 0.30. ❖ Among the series the compounds 5h showed potent anti-cancer activity. ❖ As a result, these compounds can exhibit very promising anticancer potential among the series. These could be some of the most promising targets for breast cancer cells.

Item Type: Thesis (Masters)
Additional Information: 261915006
Uncontrolled Keywords: Design, Synthesis, Characterization, Insilico Evaluation, Novel Flavone Derivatives, Anticancer Agents.
Subjects: PHARMACY > Pharmaceutical Chemistry
Depositing User: Subramani R
Date Deposited: 02 Nov 2022 17:02
Last Modified: 02 Nov 2022 18:04

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