Deepak, M (2021) A Stable Ondansetron Hydrochloride Nanosuspension for Improved Dissolution: Development, Optimization and Invitro Evaluation. Masters thesis, Karpagam College of Pharmacy, Coimbatore.
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Abstract
The present study demonstrated that ondansetron HCl loaded nanosuspension were successfully developed. • Four formulations were formulated with different stablizers and surfactants. • Out of four formulations, the formulation with the stabilizer and surfactant that resulted in low value of particle size and PDI were selected for further optimization. (T1- PS 287.3 and PDI 0.385) • The formulation with different concentration of HPMC, stabilizer (Tween 80) and sonication time were further optimized using 23factorial design. • Characterization was done for particle size, PDI and zeta potential to find out the best concentration of variables that fits the formulation. • The particle size, PDI and zeta potential was found to be in the range of 228.2 to 430.4nm, 0.392 to 0.457 and -6.87mv to -18.2mv respectively. • From the results of factorial design, the concentration of variables required to formulate the predicted particle size of 250nm was developed. • With the predicted concentration of HPMC, tween 80 and sonication time, optimized nanosuspension of OND HCl was formulated and evaluated for particle size. • The obtained particle size, PDI and zeta potential was found to be 228.2nm, 0.376 and -7.8mv respectively. • Invitro dissolution studies revealed that formulation F5 has uplifted drug release of 92.5% and 98.9% on 40 minutes at pH 1.2 and pH 6.8 respectively, whereas the marketed oral formulation released 43.2% and 49.9% on 40 minutes at pH 1.2 and pH 6.8. • The API of Ondansetron HCl released only 37.65% and 42.65% on 40 minutes at pH 1.2 and pH 6.8 respectively. • The drug release kinetics optimized nanosuspension at pH 7.4 revealed that the formulations undergone First order / anamolus / non-fickian diffusion drug release • The TEM images of the optimized formulation (F5) visualized the spherical and smooth surface of the particles in the range of 200nm to 250nm. • Hence from our study the nanosuspension of Ondansetron HCl showed faster drug release than the marketed oral formulation and API, so it is evident that formulating into nanosuspension results in improved stability, solubility and rapid drug release. CONCLUSION: It may be concluded that the nanosuspension of poorly soluble drugs such as ondansetron are easy to prepare and represent a promising novel approach for oral drug delivery. It is evident that the obtained results of invitro dissolution studies of the formulation shows improved solubility and rapid drug release. Consequently nanosuspension represent a promising alternative delivery system for improving the physiochemical properties of BCS class II drugs.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 261911401 |
| Uncontrolled Keywords: | Stable Ondansetron Hydrochloride Nanosuspension, Improved Dissolution, Development, Optimization, Invitro Evaluation. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Subramani R |
| Date Deposited: | 01 Nov 2022 17:18 |
| Last Modified: | 01 Nov 2022 17:18 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20893 |
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