Janani, S (2021) Formulation and Evaluation of Antimicrobial Mucoadhesive Dental Gel of Aerial Root of Ficus Benghalensis L to Enhance the Therapeutic activity using Clove Oil. Masters thesis, Periyar College of Pharmaceutical Sciences, Tiruchirappalli.
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Abstract
Six batches of EEARFB dental gels were prepared by using two grades of Carbopol polymer (Carbopol 940 and Carbopol 974). Based on the physicochemical parameters such as appearance, spreadability, viscosity, drug content and In-vitro diffusion studies F2 and F5 were selected as best formulations. The FTIR graphs of drugs, excipients and formulation showed that there is no extra peak or broadening of peaks were observed and thus it indicates, there is no incompatibility between drugs and excipients. From the release kinetic results, the r2 value of F5 was found to be higher in zero order release kinetics. The kinetic data of F5 formulation was fitted to Korsemeyer Peppa’s model and the value of regression coefficient r = 0.9957 and n = 1.106 which follows non -fickian (Super case II) diffusion mechanism. The amount of drug released from optimized formulation F5 (96.10%) shows a good release when compared to F2 formulation. The formulation F5 was subjected to stability studies for 3 months. At the end of 3 months the formulation F5 showed no significant changes in appearance colour, at the room temperature and 40± 2◦C & RH 75±5%. The results of antimicrobial studies showed that gel formulations of EEARFB F5 showed a maximum zone of inhibition on Streptococcus mutans. As per the drug release and antimicrobial studies, it may conclude that dental gel of F5 formulation-0.6% (Carbopol 974) shows good release and antimicrobial effect. Since the formulation F5 shows good results against Streptococcus mutans in antimicrobial studies it may be subjected to further in-vivo studies and clinical trials.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 261910203 |
| Uncontrolled Keywords: | Formulation, Evaluation, Antimicrobial Mucoadhesive Dental Gel, Aerial Root, Ficus Benghalensis L, Therapeutic activity, Clove Oil. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Subramani R |
| Date Deposited: | 01 Nov 2022 16:16 |
| Last Modified: | 01 Nov 2022 16:16 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20872 |
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