Husaain, A (2021) Formulation and Evaluation of Ivermectin Sublingual Tablet using Synthetic and Natural Superdisintegrants. Masters thesis, Periyar College of Pharmaceutical Sciences, Tiruchirappalli.
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Abstract
The λ max of Ivermectin was found to be 245nm in phosphate buffer pH 6.8. • FTIR studies showed that there was no interaction between drugs and excipients. • The sublingual tablets were prepared by direct compression method. • The pre compression parameters and post compression parameters were within the required limit F2 & F4 was selected as optimized formulation based on pre compression, post compression and in-vitro drug release. The drug release follows zero order, non-fickian super case Ⅱ transport • There was no change from its initial nature till the period of 3 months. • From the research it can be concluded that the formulation prepared by both natural and synthetic superdisintegrants showed good results in terms of pre and post compression parameters and stability studies. Since natural and synthetic superdisintegrants showed similar results, natural superdisintegrants can be used as an alternative to synthetic superdisintegrants. • Thus the study conclusively demonstrated significant results for Ivermectin sublingual tablets were more palatable and it will be beneficial to the patients for the treatment of Helminthiasis. • Further long term stability study could be done regarding the shelf life of drug, using natural superdisintegrants and also introduce In-vivo study.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 261910202 |
| Uncontrolled Keywords: | Formulation, Evaluation, Ivermectin Sublingual Tablet, Synthetic and Natural Superdisintegrants. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Subramani R |
| Date Deposited: | 01 Nov 2022 16:12 |
| Last Modified: | 01 Nov 2022 16:12 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20871 |
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