Selvi, J (2016) A study of Metabolic Syndrome in Psoriatic Patients. Masters thesis, Chennai Medical College Hospital & Research Centre, Trichy.
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Abstract
Psoriasis is a chronic immune mediated inflammatory disorder of the skin and joints. Recent studies have shown increased prevalence of traditional cardiovascular risk factors such as diabetes mellitus, hypertension and metabolic syndrome. Thyroid gland hormones cause an increase of epidermal growth factor level which has an important role in keratinocyte proliferation, which may be involved in psoriasis disease. AIMS & OBJECTIVES: To study the relationship between psoriasis and metabolic syndrome and to correlate the same with thyroid profile. MATERIALS AND METHODS: This study was conducted in Chennai Medical College Hospital and Research Centre, Irungalur, Trichy. Hundred psoriatic patients in the age group of 20-80 years in, and 30 controls were selected for this study. Fasting blood glucose by GLUCOSE OXIDASE AND PEROXIDASE method, serum lipid profile by enzymatic method and serum thyroid profile by ENZYME LINKED IMMUNOSORBANT ASSAY method. RESULTS: Our study shows that prevalence of metabolic syndrome in cases of psoriasis to be out of 37%, compared to controls among patients with other dermatological conditions to be 3.3%, (p <0.001) and shows the FT3 (pg/ml) in cases Mean to be 2.117 and in Controls Mean was 2.037, Mean difference (0.0803), p value (0.53) .Shows the mean of FT4 (pg/ml) in cases Mean (1.284), Controls Mean (1.303),and the Mean difference was (-0.0193), p value (0.809) likewise TSH (mIU/ml) in cases Mean to be (3.580), in Controls Mean (2.277), and the Mean difference was (1.303), p value (0.001). CONCLUSION: Patients of psoriasis have higher prevalence of metabolic syndrome and subclinical hypothyroidism than general population. Therefore identification of metabolic syndrome and thyroid profile testing can be done routinely for better management of psoriasis.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Metabolic Syndrome, Psoriasis, Thyroid hormones, Inflammatory Mediators. |
| Subjects: | MEDICAL > Biochemistry |
| Depositing User: | Punitha K |
| Date Deposited: | 24 Jul 2017 09:02 |
| Last Modified: | 23 May 2022 15:00 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2087 |
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