Bavya, C (2021) Preparation, Characterization and Pharmacokinetic Interactions study of Green Synthesized Silver Nanoparticles of Pterocarpus Marsupium with Antidiabetic Drug. Masters thesis, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore.
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Abstract
The current study was pursued using green synthesis of silver nanoparticles was prepared using the Pterocarpus marsupium Roxb. Bark since this method helps bark extract (Pterocarpus marsupium) to serve as a reductant and a stabilizing agent for the synthesis of AgNPs. These nanoparticles were characterized and evaluated by various test such as visual examination, uv visible spectral analysis, FTIR spectroscopy, drug entrapment efficacy, determination of particle size and zeta potential, SEM analysis, invitro antidiabetic study, invitro drug release kinetics study. Literature survey regarding diabetes mellitus have revealed that the patient administered with complementary or alternative medicine like herbal medicine along with synthetic drugs has led to the herb – drug interaction. Hence this research work has been carried out to find any pharmacokinetic interaction between green synthesized Pterocarpus marsupium silver nanoparticles with metformin and glimepiride using equilibrium dialysis method. The study was carried out by assessing percentage protein binding using metformin and glimepiride individually and in combination with green synthesized silver nanoparticles of Pterocarpus marsupium. The percentage protein binding of metformin and glimepiride individually and in combination with silver nanoparticles were found to decrease with the increase in time of contact. The concentration of metformin and glimepiride was found to get altered at different time interval. From the scatchard plot number of binding sites and affinity constant was found. The interaction study of green synthesized silver nanoparticles with metformin was observed to be increase in free drug concentration of metformin in blood plasma. The interaction study of green synthesized silver nanoparticles with glimepiride was observed to be increase in free drug concentration of glimepiride in blood plasma. Hence it can be inferred that, the concomitant administration of Pterocarpus marsupium silver nanoparticles with metformin and glimepiride should be avoided as the pharmacokinetic properties of the metformin and glimepiride was getting altered in presence of Pterocarpus marsupium silver nanoparticles.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 261910154 |
| Uncontrolled Keywords: | Preparation, Characterization, Pharmacokinetic Interactions, Green Synthesized Silver Nanoparticles, Pterocarpus Marsupium, Antidiabetic Drug. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Subramani R |
| Date Deposited: | 01 Nov 2022 03:29 |
| Last Modified: | 01 Nov 2022 03:29 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20863 |
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