Mucoadhesive Buccal Films Embedded with 5-Fluorouracil Liposomes Formulation and Characterization

Radhika, R (2021) Mucoadhesive Buccal Films Embedded with 5-Fluorouracil Liposomes Formulation and Characterization. Masters thesis, C. L. Baid Metha College of Pharmacy, Chennai.


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In the present work, an attempt was made to design and develop prolonged release liposomes by thin film hydration method. Liposomes were characterized by using encapsulation efficiency, optical microscope for structural confirmation, SEM, Zeta potential, particle size, and Ex vivo drug permeation by using Franz diffusion cell. The results showed liposomal formulation increases the penetration of the 5-Fluorouracil in biological membrane. The liposomes are intended to be formulated as mucoadhesive buccal film of 5-Fluorouracil liposomal using polymers HPMC and SCMC. Different polymer concentrations were used in the formulation. The buccal film was evaluated for weight, thickness, Surface pH, Percentage Moisture Absorption, Percentage Moisture loss, folding endurance, drug content uniformity and Ex-vivo permeation study. The Jss o 5-Fluorouracil from F4 was found 9.4802 mg cm-2 h-1, the result indicates 8.53 times higher than compared to free drug. The study confirms that amount of polymers in buccal film formulation plays an essential role in the physicochemical properties and permeability through Goat buccal skin. The kinetics of the drug permeation through excised buccal tissue of goat was studied to determine the mechanism of drug release from the buccal film. The best polymer composition was selected from the various ratios of the polymers. The polymer ratio was found to be HPMC and SCMC in ratio 4.9:2.5 (F4). The F4 formulation shows satisfactory results in the parameters such as Weight, thickness, Surface pH, percentage moisture absorption and loss, folding endurance, drug content and diffusion studies. Buccal films have potential to control the release over the period of 10 hours. The Buccal film formulation decreases dosing frequency, avoids gastric irritation, reduces cytotoxicity, avoids first pass metabolism and improve bioavailability of the drug. Further work will be carried out in order to determine its efficacy and safety by pharmacokinetic and pharmacodynamics studies in animals.

Item Type: Thesis (Masters)
Additional Information: 261910012
Uncontrolled Keywords: Mucoadhesive Buccal Films, Embedded, 5-Fluorouracil Liposomes, Formulation, Characterization.
Subjects: PHARMACY > Pharmaceutics
Depositing User: Subramani R
Date Deposited: 01 Nov 2022 03:05
Last Modified: 01 Nov 2022 03:05

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