Karthick, M (2021) Analytical Method Development and Validation of Rosuvastatin and Clopidogrel in Tablet Assay by RP-HPLC Method. Masters thesis, Annai J.K.K. Sampoorani Ammal College of Pharmacy, Komarapalayam.
Full text not available from this repository.Abstract
A RP-HPLC method for ROSUVASTATIN AND CLOPIDOGREL was developed and Validated in tablet dosage form as pre ICH Guide lines. UV visible Detector and Column C18(240 × 4.6mm)5µ injection of 20µl is injected and eluted with the mobile phase of Acetonitrile : water and 0.1 ml triethylamine and 0.5% trifluroacetic acid (75:25 v/v) in the ratio 75:25 which was pumped at a flow rate of 1.0ml at 288nm. The peak of Rosuvastatin and Clopidogrel was found well separated within 13min. The developed method was validated for various parameters as per ICH guidelines like system suitability, linearity, system precision, method precision, recovery, robustness, LOD& LOQ. The analytical method validation of Rosuvastatin and Clopidogrel n and by RP-HPLC method was found to be satisfactory and could be used for the routine pharmaceutical analysis of Rosuvastatin and Clopidogrel.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 261930706 |
| Uncontrolled Keywords: | Analytical Method, Development, Validation, Rosuvastatin, Clopidogrel, Tablet Assay, RP-HPLC Method. |
| Subjects: | PHARMACY > Pharmaceutical Analysis |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 30 Aug 2022 06:04 |
| Last Modified: | 30 Aug 2022 06:04 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20828 |
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