Mouli Kanth, C S (2021) In Vitro Evaluation of Anti Angiogenisis Activity of Modified Thiazolidinedione Derivative through Anti Cancer Activity. Masters thesis, Cherraan’s College of Pharmacy, Coimbatore.
Full text not available from this repository.Abstract
Synthesized thiazolidinedione derivative were screened for their in-vitro anti-cancer activities and found most of them having significant anticancer activities. The pharmacological events showed by synthesized novel thiazolidinedione's derivatives have confirmed that these compounds may serve the purpose of being accepted as the novel therapeutic agents. Furthermore, these novel thiazolidinedione's derivatives may be optimized by their toxicity and SAR studies Three thiazolidinediones had been approved for the treatment of cancer: troglitazone, rosiglitazone and pioglitazone. Rosiglitazone and pioglitazone are widely available; troglitazone has been removed for causing severe hepatotoxicity. In order to reduce side effects and increase the efficacy of TZDs, research is in continuous process Unfortunately, clinically used TZD class of medications suffered from various serious side effects like hepatotoxic-ity, oedema (fluid retention) and weight gain as a result of troglitazone and rosiglitazone were banned and the pioglitazonehas shown to increase the risk of bladder cancer. This review emphasizes TZDs not only as a fortunate and potential scaffold inthe field of medicinal chemistry but also outlined the chemistry and biological activities of the TZDs scaffold as anticancer agents. The synthetic methodologies signify simplicity and versatility, which offer the medicinal chemist to discover a complete range of novel derivatives. In our finding is we are performed in vitro methods like antioxidant studies indicated powerful free radical inhibition property, Angiogenesis activity shown milder and MTT assay expressed moderate cell growth inhibition. Above studies correlated in our drug have anti-angiogenesis property through anticancer activity. Clinical trials of adequate power and duration are required to clarify the role that PPAR-y activation may have in the treatment of cancer. Based on the available study results, TZDs can be considered as one of the promising classes of compounds that can overcome future problems.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 261925855 |
| Uncontrolled Keywords: | In Vitro Evaluation, Anti Angiogenisis Activity, Modified Thiazolidinedione Derivative, Anti Cancer Activity. |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 18 Aug 2022 01:53 |
| Last Modified: | 28 Aug 2022 09:35 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20790 |
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